@phdthesis{Wilhelm,
  type      = {Bachelor Thesis},
  author    = {Susen Wilhelm},
  title     = {Zur Interpretation forensischer DNA-Mischspuren : Auswertung mittels GenoProof Mixture Software unter besonderer Ber{\"u}cksichtigung der Dekonvolution},
  abstract  = {Background: Forensic molecular genetics deals with ancestry and trace investigations. These analyzes are based on the investigation of short tandem repeats, which result in individual- specific STR profiles. The characteristic profiles of traces can`t often be assigned to just one person. One problem with DNA mixtures in the analysis of the DNA profiles is the superposition of individual peaks in the electropherogram, so that the allelic peaks can`t be differentiated from one another. One application of the GPM 3 software is the component- by- component deconvolution of DNA mixtures, in which the profiles of the persons involved are separated and the weighting of all possible genotypes are counted. The deconvolution should be performed using the completely continuous model using different 2- person mixtures in different concentrations. Results: Based on this data, a limit value of around 30\% was determined for the 2-person mixture, by which two genotype constellations may maximally be the same, so that the calculated genotype constellation agrees with the \"true\" one with a high probability. This value applies to the genotype constellations with a weighting of less than 90\%. Conclusions: This report deals with the investigation of individual- specific STR profiles created by different 2- person profiles. The most likely genotype constellations of the people involved were counted and weighted using the component- wise deconvolution of GenoProof Mixture 3. Based on the spacing of the weightings, a value for the minimal spacing, from which the “true” genotype constellation is calculated with a high probability, was determined.},
  language  = {de}
}