OPUS


Analysis and Classification of Transcription Data for the Detection of Potential Biomarkers in Cancer

  • Cancer is one of the main causes of death in developed countries, and cancer treatment heavily depends on successful early detection and diagnosis. Tumor biomarkers are helpful for early diagnose. The goal of this discovery method is to identify genetic variations as well as changes in gene expression or activity that can be linked to a typical cancer state. First, several cancer gene signaling pathways were introduced and then combined. 27 candidate genes were selected, through the analysis of several data sets in the GEO database, a few expression difference matrices were established. Those candidate genes were tested in the matrices and found five genes PLA1A, MMP14, CCND1, BIRC5 and MYC that have the potential to be tumor biomarkers. Two of these genes have been further discussed, PLA1A is a potential biomarker for prostate cancer, and MMP14 can be considered as a biomarker for NSC lung cancer. Finally, the significance of this study and the potential value of the two genes are discussed, and the future research in this direction is a prospect.

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Metadaten
Author:Yantao Gao
URN:urn:nbn:de:bsz:mit1-opus4-84303
Title Additional (German):Analyse und Klassifizierung von Transkriptionsdaten für die Detektion von möglichen Biomarkern bei Karzinomen
Document Type:Master's Thesis
Language:English
Year of Completion:2016
Granting Institution:Hochschule Mittweida
Release Date:2018/03/12
GND Keyword:Biomarker , Krebs <Medizin>
Institutes:Angewandte Computer‐ und Bio­wissen­schaften
Access Rights:Frei zugänglich
Licence (German):License LogoEs gilt das UrhG