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FRET-assisted structural model of the GAAA RNA tetraloop receptor

  • Long-range tertiary interactions between RNA tetraloops and their receptors stabilize the folding of ribosomal RNA and support the maturation of the ribosome. Here, we use FRET-assisted structure prediction to develop a structural model of the GAAA tetraloop receptor (TLR) interaction and its dynamics. We build the docked TLR de novo, label the RNA in silico and compute FRET histograms based on MD simulations. The predicted mean FRET efficiency is remarkably consistent with single-molecule experiments of the docked tetraloop. This hybrid approach of experiment and simulation will promote the elucidation of dynamic RNA tertiary contacts and accelerate the discovery of novel RNA and RNA-protein interactions as potential future drug targets.

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Metadaten
Author:Felix Erichson
URN:urn:nbn:de:bsz:mit1-opus4-122837
DOI:https://doi.org/10.48446/opus-12283
ISSN:1437-7624
Parent Title (German):26. Interdisziplinäre Wissenschaftliche Konferenz Mittweida
Publisher:Hochschule Hochschule Mittweida
Place of publication:Mittweida
Document Type:Conference Proceeding
Language:English
Year of Completion:2021
Publishing Institution:Hochschule Mittweida
Contributing Corporation:Laserinstitut Hochschule Mittweida
Release Date:2021/05/17
Tag:GAAA tetraloop; MD simulation; hybrid modeling
GND Keyword:Fluoreszenz-Resonanz-Energie-Transfer; RNS
Issue:002
Page Number:4
First Page:230
Last Page:233
Open Access:Frei zugänglich
Licence (German):License LogoEs gilt das UrhG