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Transcriptome progression in community acquired pneumonia

  • Community acquired pneumonia (CAP) is a very common, yet infectious and sometimes lethal disease. Therefor, this disease is connected to high costs of diagnosis and treatment. To actually reduce the costs for health care in this matter, diagnosis and treatment must get cheaper to conduct with no loss in predictive accuracy. One effective way in doing so would be the identification of easy detectable and highly specific transcriptomic markers, which would reduce the amount of work required for laboratory tests by possibly enhanced diagnosis capability. Transcriptomic whole blood data, derived from the PROGRESS study was combined with several documented features like age, smoking status or the SOFA score. The analysis pipeline included processing by self organizing maps for dimensionality and noise reduction, as well as diffusion pseudotime (DPT). Pseudotime enabled modelling a disease run of CAP, where each sample represented a state/time in the modelled run. Both methods combined resulted in a proposed disease run of CAP, described by 1476 marker genes. The additional conduction of a geneset analysis also provided information about the immune related functions of these marker genes.

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Author:Martin Zerbst
Advisor:Dirk Labudde, Hans Binder
Document Type:Master's Thesis
Year of Completion:2018
Granting Institution:Hochschule Mittweida
Release Date:2019/10/15
GND Keyword:Lungenentzündung; Patient; Datenbank; Forschung; Systemmedizin
Institutes:Angewandte Computer‐ und Bio­wissen­schaften
Dewey Decimal Classification:610.113 Systemmedizin
Open Access:Frei zugänglich
Licence (German):License LogoEs gilt das UrhG