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The Infinica product suite consists of multiple individual microservice applications, mainly gathered around Infinica Process Engine which allows the execution of highly individualised process definitions. For estimating process performance, a layered queuing network approach has been applied. In the first step this required the implementation of a basic modelling framework. Subsequently the implemented framework was used to evaluate the applicability of the approach by creating two models and comparing them with actual performance measurements. Although the calculated results deviated from the expected results, analysis showed that the differences may
derive from an inaccurate model. Nevertheless the general approach seems to be appropriate for the given application as well as for microservices in general, especially when extended with advanced modelling techniques, as the analysed modelled results appear consistent.
Prototype-based classification methods like Generalized Matrix Learning Vector Quantization (GMLVQ) are simple and easy to implement. An appropriate choice of the activation function plays an important role in the performance of (deep) multilayer perceptrons (MLP) that rely on a non-linearity for classification and regression learning. In this thesis, successful candidates of non-linear activation functions are investigated which are known for MLPs for application in GMLVQ to realize a non-linear mapping. The influence of the non-linear activation functions on the performance of the model with respect to accuracy, convergence rate are analyzed and experimental results are documented.
The bachelor thesis is assigned to introduce the theoretical concept of Human Recourses Management, to analyze the work of human resources department of the LLC Tavria-V and to offer actions with recommendation to improve the productivity of the personnel. To start the implementation of actions for personnel management improvement, first of all, an overview of theoretical and methodological aspects of the HRM are presented and theories which earlier had an impact on our present running of the "workers" are described. Secondly, the concept of organizational work of the enterprise, main indexes and types of activities are figured out and in the form of tables and diagrams analyzed. The main object of the thesis - the process of personnel management with qualitative characteristics is described and presented. Using also the survey of employee all advantages and disadvantages of the present system of HRM are defined. Then in the last part, taking to account all data about current situation, recommended actions and effect for LLC Tavria-V on the basis of the personnel management analysis are presented in the work.
Cryptorchidism describes a disease, in which one or both testes do not descend into the scrotum properly. With a prevalence of up to 10%, cryptorchidism is one of the most common birth defects of the male genital tract. Despite its associated health risks and accompanying economic damage, resulting from surgery and losses in breeding, studies on canine cryptorchidism and its causes are relatively rare. In this study a relational database for genetic causes of cryptorchidism was established and used as a basis for the identification of candidate genes. Associated regions were analysed by nanopore sequencing with the goal to identify genetic variants correlated with cryptorchidism in German Sheep Poodle.
In this thesis, the changes in economy and society and the resulting effects on the labor market are being outlined. Current studies show that the shrinking labor market and the increasing digitalization result in a lack of skilled tech talent and a transition from an employer market to a clear employee market. Derived from the findings of the scientific research on this topic and conducted expert interviews, practical recommendations for recruitment actions within the scope of employer branding will be defined in order to help corporations to gain the needed tech skill set and drive innovation.
The epithelial membrane proteins (EMP1-3), which belong to the family of peripheral myelin proteins 22-kDa (PMP22), are involved in epithelial differentiation. EMP2 was found to be a downstream target gene of the tumor suppressor gene HOPX, a homeobox-containing gene. Additionally, a dysregulation of EMP2 has been observed in various cancers, but the function of EMP2 in human lung cancer has not yet been clarified.
In this study, a real-time RT-PCR, Western blot and cytoblock analysis were performed to analyze the expression of EMP2. Gain-of-function was achieved by stable transfection with an EMP2 expression vector and loss-of-function by siRNA knockdown. Stable transfection led to overexpression of EMP2 at both mRNA and protein levels in the transfected cell lines H1299 and H2170.
Functional assays including proliferation, colony formation, migration and invasion assays as well as cell cycle analyzes were performed after stable transfection and it was found that the ectopic EMP2 expression resulted in a reduced cell proliferation, migration and invasion as well as a G1 cell cycle arrest. After the EMP2 gene was silenced by the siRNA knockdown, inhibition of the cell invasive property was observed. These phenomena were accompanied by reduced AKT, mTor and p38 activities.
Taken together, the data suggest that the epithelial membrane protein 2 (EMP2) is a tumor suppressor and exerts its tumor suppressive function by inhibiting AKT and MAPK signaling pathways in human lung cancer cells.
The aim of this bachelor thesis was to establish extracytoplasmic function (ECF) σ factors as synthetic genetic regulators for biotechnological and synthetic biology applications in the new emerging model organism Vibrio natriegens. Therefore, synthetic genetic circuits were engineered on plasmids as test set-up for the investigated ECFs and their target promoters. The resulting plasmid library consisted of the reporter plasmids with the target promoter, fused to a lux cassette, a set of high-copy ECF plasmids and a backup set of lower-copy ECF plasmids. First, the high-copy plasmids were transformed in V. natriegens to test them for their functionality upon different inducer levels, which yielded good inducibility for few, but showed too high ECF-expression in most strains. For this reason, the set of lower copy plasmids was used for combinatorial co-transformation, to investigate the ECFs for their cross-talk to unspecific ECF target promoters. The switching to the lower-copy plasmid-set seemed to be partly helpful, while still much room for fine-tuning of the circuits remains. The knowledge gained can be used to achieve higher success rates when engineering synthetic circuits for various applications in V. natriegens, by using the ECFs here recommended as suitable synthetic genetic regulators.
Workload Optimization Techniques for Password
Guessing Algorithms on Distributed Computing Platforms
(2019)
The following thesis covers several ways to optimize distributed computing platforms for cryptanalytic purposes. After an introduction on password storage, password guessing attacks and distributed computing in general, a set of inital benchmark results for a variety of different devices will be analyzed. The shown results are mainly based on utilization of the open source password recovery tool Hashcat. The second part of this work shows an algorithmic implementation for information retrieval and workload generation. This thesis can be used for the conception of a distributed computing system, inventory analysis of available hardware devices, runtime and cost estimations for specific jobs and finally strategic workload distribution.
In today’s market, the process of dealing with textual data for internal and external processes has become increasingly important and more complex for certain companies. In this context,the thesis aims to support the process of analysis of similarities among textual documents by analyzing relationships among them. The proposed analysis process includes discovering similarities among these financial documents as well as possible patterns. The proposal is based on the exploitation and extension of already existing approaches as well as on their combination with well-known clustering analysis techniques. Moreover, a software tool has been implemented for the evaluation of the proposed approach, and experimented on the EDGAR filings, on the basis of qualitative criteria.
In the present bachelor thesis, nanopore sequencing and Illumina sequencing was compared using pollen DNA collected from honeybees and bumble bees. Therefore, nanopore sequencing was performed with the MinION sequencers and the generated reads were analysed with bash programming. A quantitative and qualitative (based on ITS2 sequences) BLAST run was performed. The results confirme the error probability of nanopore sequencing that is described in the literature. Nevertheless, with both sequencing methods similar sample preferences of the bees could have been observed, allowing ecological conclusions.