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Functions, which can be summarized to the keyword Internet Protocol Television (IPTV) describe the transmission of video services to users via Internet Protocol (IP). Accompanying to this new television transmission path Home Theatre PCs (HTPC) running a so called Media Center platform are more and more entering the living rooms as a companion for the popular LCD and Plasma displays. Perfect ease of use and the visual integration on the screen and also into the living room is raising their acceptance. These HTPCs are a central node for multimedia services such as TV, radio and email within the networked household. Thus, there are good preconditions for the use of a HTPC as end device for Telco operator driven IPTV and telecommunication services. In the context of this diploma thesis possibilities for the provisioning of IPTV and Next Generation Network (NGN) services on a converged multimedia home entertainment platform for the living room will be investigated, especially Vista Media Center platforms. For this reason, standardization activities will be investigated, which deal with the integration of IPTV and telecommunication services into NGN. The validation of the results will be achieved by the design and implementation of a Vista Media Center Add-In, which can be integrated as an IP Multimedia Subsystem (IMS) based User Agent (UA) in ETSI TISPAN Release 2 IPTV infrastructures. Additionally, a Cross Domain messaging service for IMS based UA is created, which enables a cross-network communication between users.
The H.323 umbrella standard describes audiovisual communication over packetswitched networks. This thesis illustrates the standard in detail with regards to architecture and implementation. The second part of this dissertation is dedicated to examining the Gmail Voice and Video plug-in, an Internet-based audiovisual communication platform. In the course of this thesis a secured kiosk environment for the Gmail Voice and Video plug-in is being developed.
When entering waterways that are restricted either in height, width or by another vessel, the behaviour of a ship changes. The most evident effect of navigating in shallow water is the squat which has led to several groundings. Because of pressure differences the vessel is pulled down into the water and the trim is changed. Another shallow water effect is the speed loss due to an increase in resistance which can reduce the maximal speed by upto 50 percent. In general the behaviour of a ship in shallow water is said to be sluggish, meaning that it is more difficult to navigate which affects the radius of the turning circle among others. Sailing parallel to a close-by bank affects the lateral force and the yaw moment. The interaction with other ships has similar effects as bank effects, but is more sophisticated since more parameters play a major role. In this thesis each of these effects is researched by studying several papers by renowned researchers.
Several models are developed which are correspondent with the inherent model of forces and moments of the simulation program. The challenges and obstacles that arised during modelling and implementation are pointed out and solutions or approaches are given.
The Media System of Malawi
(2010)
nicht vorhanden
The aim of this master thesis is to describe the key factors of successful energy efficiency projects. In particular, local conditions of such projects in Kazakhstan will be emphasized and a country-specific guideline will be provided at the end. The following topics will be covered in this thesis: energy efficiency technologies, financing, and capacities. The first part examines the energy efficiency approaches and their potential in the local industry. The second part deals with available financing methods, their specific characteristics and appropriateness for overcoming investment barriers in Kazakhstan. The third part of the master thesis concerns necessary project capacities. The application of the three elements for successful project implementation is described in the end.
The thesis presents an investigation of the question whether it is viable for the English company Essential Care to introduce a direct selling channel in the United Kingdom. The thesis provides an outline of the direct selling and labour market in the United Kingdom, including organisations and legislation for direct selling. A SWOT analysis illustrates the external and internal factors that could have an influence on the feasibility of the project. The main part of the thesis focuses on a market research survey which was conducted in the United Kingdom. Followed by an analysis of the results it provides a detailed outline of the findings. At the end of the thesis the overall findings are summarised and recommendations for Essential Care are presented.
The primary objective of this work and the research at the “Helmholtz-Zentrum für Umweltforschung” was to gain a deeper understanding of the basically transformation processes, especially for nitrogen species, in constructed wetlands. Therefore two different types of laboratory scale model systems, run with two different artificial wastewaters, had been observed for about 4 months. Data about the situation of three nitrogen species (ammonium, nitrate, nitrite), the physical condition of the pore water and the carbon sources contained by the water had been collected and compared. The present work will provide a summary about the actual knowledge of the microbial processes in constructed wetlands and the general character of such constructions. It will explain the different methods used to gain the data which will be later wards discussed with the aid of the created graphs in the final argumentation.
nicht vorhanden
The bachelor thesis is about cis-trans isomerization of Xaa-Pro (Xaa = any amino acid), their quantitative acquisition and the selection of 3D structure information for the prediction with a support vector machine (SVM). The quantitative detection of occurrence of cis-, trans- and cis/trans conformation in membrane proteins will be examined and evaluated. The 3D structure informa-tions include 12 features, the amino acids around proline and are including of proline. These include the inside/outside classification, the real secondary structure, energy consideration, as well as five further amino acid occur properties within a defined radius of the proline. From this information, a data set was created for the SVM. This program is used for the prediction of unknown and known Xaa Pro Isomerisms. The methods for the analysis were implemented with the platform independent programming language Java. Two programs have emerged from the work to a Xaa PIPT for the quantitative detection and extracting structural information and m Xaa-PIPT to the pure prediction of Xaa-Pro isomerism in protein structures. 389 Membrane proteins from the PDB (Protein Data Bank) served as a basis. The data were also statistically analysed and evaluated.
In this work a new method for the prediction of the Xaa-proline (where Xaa is any amino acid) cis/trans isomerization was investigated. By extraction of twelve structural features (real secondary structure, inside/outside classification, properties of the environment around proline and proline itself) a support vector machine (SVM) based prediction approach was evolved. The Java software Xaa-PIPT for structural feature extraction was developed. Based on 4397 (2199 cis and 2198 trans) prolines extracted from non-redundant, globular proteins a classifier was trained using the radial basis function (RBF) kernel. In ten-fold cross-validation it achieved an accuracy of 70.0478 % and a Matthews correlation coefficient (MCC) of 0.4223, a sensitivity of 0.5433 and a specificity of 0.8576. Based on this classifier a lightweight and easy-to-use Java software tool, called m Xaa-PIPT, for the prediction of the Xaa-proline cis/trans isomerization was devel-oped. It was shown that there are correlations between the proline surrounding environment and the isomerization state. m Xaa-PIPT can be used for the evaluation of low-resolution protein structures and theoretical models to improve their quality by the prediction of the Xaa-proline isomerization.
After the expression of the titin-Hsp27-construct with the following purification supplies no satisfied results which makes the realization of the atomic force microscopy not possible. The devel-opment of the structure model by using different bioinformatic methods can establish a model for the protein sequence. As bioinformatic methods the template search by different BLAST runs and free available software like SwissModel, Pcons, ModWeb and other tools are used. Nevertheless, the generated model is not the native conformation and has to be analyzed with other software until a stable conformation of the structure can be predicted. Depending on the time which is provided the generated model is a good approach for the aim this master thesis has.
This thesis looks at Customer Relationship Management in a different way. In order to identify factors that influence the acceptance of one of its components – the analytical CRM – it focuses on theopinion of the company’s employees. The objective of this thesis is to identify factors that positvely influence the acceptance of analytical Customer Relationship Management within organizations.
This paper explores the origins of Maori images in New Zealand film history. Discussing the history of Maori and their society brings us closer to a, once almost extinct, race and its struggle for self-representation and self-governance. By taking an in-depth look at New Zealands film history we get to understand how Maori were the subject of the earliest films and at what time they started making their own films. Combining those elements gives us the opportunity to understand how early images of Maori were created by Pakeha directors. By looking at different films throughout film history shows how Maori images evolved in time, especially when Maori started depicting themselves. This paper not only answers questions about Maori images in film but also tries to make people realise what odds Maori had to overcome in their daily struggle for selfdetermination.
This feasibility study shows possibilities, how logistical concepts can be
improved or reorganized. Therefore, the assambly line for hydraulic blocks at
Bosch Rexroth Changzhou is checked and new ideas are shown. To ensure
comparability, three different cases are considered. Based on this evaluation,
recommendations for further development are displayed.
Die vorliegende Arbeit befasst sich mit der Leistungsmessung während der Strategieentwicklung im Bereich des Einkaufs am Beispiel DANIELI Österreich. Das Hauptziel ist es, dass System von Danieli Österreich darzustellen, um ein Verständnis der Leistungsmessung in der Praxis zu generieren. Die draus erworbenen Kenntnisse sollen weiterführend in einer Analyse dazu dienen, um die tatsächlichen Einsparung in diesen Ländern aufzuzeigen. Aufgrund Vorgaben der Geschäftsführung ist DANIELI Österreich gezwungen 20% seines Einkaufsvolumens im ehemaligen Jugoslawien einzukaufen, weshalb Möglichkeiten sowie Risiken in den Ländern Bosnien und Herzegowina, Serbien und Kroatien dargestellt werden, um die Einkaufsstrategie zu optimieren.
Different small molecule kinase inhibitors, which have an influence on cell growth, proliferation and cell survival were tested alone and in combination with Erlotinib in the Erlotinib-resistant non-small cell lung cancer cell line PC-9ER and Cisplatin in the K-Ras mutant cell line H358. The aim was to find out, which combinations produce the best antiproliferative effects in non-small cell lung cancer cell lines.
The larval zebrafish mutant Knörf has got a not yet identified gen, which is lethal after 14 dpf in a homozygous state. The mutation courses various degenerations and the loss of the regeneration ability. One of these degenerations was first discovered in the retina by a histological section. The mutants retinas show gaps in the IPL at 7 and 8 dpf which number increases during the maturation of the larva. In recent studies a pax 6 staining was performed, which showed that amacrine cells areaffected. Different types of amacrine cells were tested and it was shown that the parvalbuminergic amacrine cells disappear. The staining was performed in a time course. At 5 dpf is no difference between the number of parvalbuminergic amacrine cells in siblings and mutants but then the degeneration starts. At 2 dpa there is thefirst significant difference which increases at later stages and leads nearly to a full disappearance of these cells in the eye. Parvalbumin is not only present in the retina, therefore the brain as another central nervous system structure was examined. In the telencephalon these cells disappear already at 2 dpa. The parvalbuminergic cells are also present in the skeletal muscle of the tail. Here the degeneration starts approximately at the half of the tail and intensifies to distal areas. It was shown, that parvalbuminergic cells in the muscle disappear until 4dpa. The role of parvalbumin is seemed in the binding ofcalcium and therefore it supports the adjustment of the resting potential after an excitation in the central nervous system. In muscles it assists in the slowing of relaxing after a contraction of a muscle.
The main purpose of this thesis is to investigate factors influencing the buying decision of cigarette smokers. To achieve this, different theories concerning consumer buying behavior and factors influencing have been discussed to achieve a deeper understand of consumer behaviour. To enable me comprehend the influence factors that influence the buying decision of a smoker as a consumer, a survey with questionnaires was performed. The results of the survey indicates that brand awareness, quality of the tobacco, price, packaging, advertisement, influence by others and availability are the major factors influencing the buying decision of a smoker, with availability, quality, price and brand awareness having the most effective influence on a smoker.
Proteins are macromolecules that consist of linear-bonded amino acids. They are essential elements in various metabolic processes. The three-dimensional structure of a protein is determined by the order of amino acids, also referred to as the protein sequence. This conformation corresponds to the structural state in which the protein is functionally active. However, relationships between protein sequence, structure and function have not been fully understood yet. Additionally, information about structural properties or even the entire protein structure are crucial for understanding the dynamics that define protein functionality and mechanisms. From this, the role of a protein in its molecular context can be described closely. For instance, interactions can be investigated and comprehended as a biological dynamic network that is sensitive to alternations, i.e. changes which are caused by diseases. Such knowledge can aid in drug design, whereas compounds need to be specifically tailored and adjusted to their molecular targets. Protein energy profile-basedmethods can be applied to investigate protein structures concerning dynamics and alternations. The publications enclosed to this work discuss in general the scientific potentials of energy profilebased techniques and algorithms. On the one hand, changes in stability caused by protein mutations and proteinligand interactions are discussed in the context of energy profiles. On the other hand, energetic relations to protein sequence, structure and function are elucidated in detail. Finally, the presented discussions focus on recent enhancements of the eProS (energy profile suite) database and toolbox. eProS freely provides all elucidated methodologies to the scientific community. Thus, one can address biological questions with the presented methods at hand. Additionally, eProS provides annotations related to foreign databases. This ensures a broad view on biological data and information. In particular, energetic characteristics can be identified which contribute to a protein’s structure and function.
The objective of this diploma thesis is to analyse the results of functional tests carried out on hydraulic valve blocks at Wujin Plant of Bosch Rexroth (Chang-zhou) Co., Ltd., (China). Based on this analysis, tests could be checked for systematic errors and root causes of failures be identified. Finally, this helped i n-crease the first pass yield of testing to release resources so far bound in inefficient testing processes. Furthermore, a tracking mechanism was established to monitor the function of crucial sensors at test benches.
nicht vorhanden
This thesis deals with the possible integration of social media communication in the marketing of the International Rectifier Corporation. The basis for the implementation of the new communication channel is set through a detailed description of basic, theoret ical functions and features of business-to-business communication as well as social media communication. Based on this knowledge the marketing communication of International Rectifier is analyzed and compared to the competitors. The theoretical lessons in combination with the analysis will then be used to develop a competitive and effective social media strategy for International Rectifier.
There are a lot of people taking part in more than one competition. The competitions are also of a different kind. From local events with a small number of participants to international tournaments watched by many viewers. Naturally it becomes necessary a system to assess and compare the success in various competitions.
The existing ranking systems are usually specialized to fit their application area. More general ranking methods also exist. They can be applied to a wide spectrum of competition fields. However these ranking methods are still not universal and don't cover some important features of the competitions.
A totally new ranking system has been developed within the present master thesis. Its primary purpose is to evaluate and measure prestige gained by participants in competitions. The main contribution of the thesis consists of an original mathematical model that makes the ranking system unique.
The developed ranking system claims to be universal and interdisciplinary. It is based on the fundamental element that distinguishes the competition from the non-competition areas, namely standings that rank the participants according to their performance. The universality and the interdisciplinarity of the ranking system make available cross-disciplinary comparisons, which is usually very subjective and difficult for implementation.
The contribution of the master thesis extends beyond the theoretical area. A ranking software that fully implements this novel ranking system has been designed and developed. The software makes the practical benefits of the ranking system immediately available to potential application areas such as sports clubs and universities.
And finally, the developed ranking system offers a new viewpoint to the competitions – as a way of gaining prestige, rather than the traditional viewpoint of demonstrating mastery.
This master thesis investigates a new method for the feature extraction of gray scale images, the so called „Non-Euclidean Principal Component Analysis“ 1. Thereby the standard inner product of the Euclidean space is substituted by a semi inner product in the well known learning rule of Oja and Sanger. The new method is compared with the standard principal component analysis (PCA) by extracting features (feature vectors) of different databases with class labels and judged regarding the accuracies of „Border Sensitive Generalized Learning Vector Quantization“ (BSGLVQ), „Feed Forward Neural Networks“ (FFNN) and the „Support Vector Machines“ (SVM).
This study shows the potential for the make-or-buy theory in several scenarios – production, assembling and development. The evaluation of these possibilities is conducted, based on Bosch’s core competencies. A decision model is developed to support the decision making process. Based on these results, the serial production at RBAC in China is planned and suggestions for setting up the assembly line are given
Target of this Diploma Thesis is the development of a thermal simulation card to analyze the thermal behavior of a LTE PCIe Mini data card for GSM/UMTS based wireless networks in different environments. The power consumption of modern wireless communication systems has increased dramatically during the last years. Especially for the next generation of wireless modem cards the thermal dissipations will be slightly on or even beyond the official guidelines of the components and the whole card. To gain knowledge about the behavior of the data card, it shall be simulated with software as well as real hardware. As the ASIC components are not available yet, a hardware emulation shall be developed. The thesis covers the whole development process from the idea, the conception, the layout to the assembly and the measurements. It starts with finding a way of emulating the mounted components, measuring and powering. Afterwards a card, incorporating the principles found before, will be developed. An additional software simulation gives comparative values against the measurements. After assembling the emulation cards and running reference measurements, trials for temperature improvements will be ran and compared with the simulations.
The main purpose of this Bachelor thesis was to find and to compile comprehensive information on barley genes expressed in the context of pollen embryogen esis. In the present study, this approach was confined to genes that were previously known to be associated with the initiation of embryogenesis in different plant species. First, candidate transcript sequences were identified in barley. Second, transcript and associated genomic sequences were analyzed in silico to provide suitable structural and functional annotations. Finally, the results of one representative example are presented and interpreted in detail. This work aims to contribute to a significantly improved understanding of pollen embryogenesis - a biological phenomenon broadly used for haploid technology in crop improvement.
In this work a novelty detection framework provided by M. Filippone and G. Sanguinetti is considered, which is useful especially when only few training samples are available. It is restricted to Gaussian mixture models and makes use of information theory, applying the Kullback-Leibler divergence. In this work two variations of the framework are presented, applying the symmetric Hellinger divergence and a statistical likelihood approach.
The study “Proteomic and systems biological database analysis of changed proteins from rat brain tissue after diving “ is about system biological testing of proteomic data obtained by rat brain after experimental diving in a pressure chamber. Basically, brain tissue from animal decompression sickness (DCS) was analyzed by mass spectrometry and has given two larger sets of modified proteins. Thereupon, the resulting up- and down-regulated proteins wereidentified and later compared by means of systems of biological databases, in this case GeneGo MetaCoreTM, in order to find similar or various affected cell biological signaling pathways when two different mass-spectrometry methods were compared.
This work concentrates on the frequently used marketing instrument brand personality. Its effect on the consumer and how it drives consumer behaviour through TV advertis-ing are the focus. Scientific material, utilising research results of the last 20 years, has been analysed to investigate this subject. Furthermore, the example of Southern Comfort provides an insight of brand personality being applied to the real world of marketing business.
For the first time it was discovered that ultraviolet radiation with a wavelength of 200 to 400 nm (maximum 365 nm) radiated from a distance of 40 cm (intensity: 3500 mW/cm²) to PMMA altered its surface wettability as well as a roughness at the nanoscale that was observed with an atomic force microscope (AFM). The roughness rises and falls again in a short time ( 1-2days ) after 75 min and 180 min irradiation time. However , during the next 10 days roughness became stabilized and there was no influence of UV if PMMA was stored in air or in a Petri dish out of glass.
nicht vorhanden
This Bachelor thesis provides an experimental validation of the “si-Fi” software, which was designed for RNAi off-target searches and silencing efficiency predictions. The experimental approach is based on using synthetic DNA as RNAi-target as well as RNAi-trigger sequence. The data was generated by two different types of experiments using a transient gene silencing system in bombarded barley epidermal cells. The efficiency of RNAi was estimated by scoring the effect of silencing of the susceptibility-related gene Mlo on resistance of transformed cells to the powdery mildew fungus Blumeria graminis f. sp. hordei by observing reduction of fluorescent signals coming from an RNAi target fused to the green fluorescent protein. The aim of this work was a comparison between in silicio prediction of RNAi efficiency and off-target effects in barley and experimental data.
In recent years the term Cloud has become popular in the world of technology. It is used to describe many different Information Technology offerings, but people are adapting this word without truly understanding it. “Demystifying the Cloud – Drawing the Lines between Technologies and Concepts” by Kevin Arnot takes a look at many levels of the Cloud and gives a comprehensive overview of the technologies and ideas that make it a paradigm shift. The author analyzes the term methodically by leveraging appropriate information from the Internet as well as from experts. An important milestone in understanding the Cloud accurately is differentiating between its components. These include: underlying technologies, the three Cloud Service Models (SaaS, IaaS and PaaS) and how it is deployed, publically or privately. The result is to understand that a Cloud can be composed in different ways and therefore serves exactly the needs of its users. Furthermore, the author describes challenges that individuals and busi-nesses have to deal with equally and reviews possible solutions. Cloud technology will continue to evolve; however, the future business value of the term “Cloud” will depend on how companies continue using or misusing it.
This work examines the impact Web 2.0 has on CRM in journalism. For this purpose the communication strategies of one international, one New Zealand and one exclusively online men’s magazine are compared. Through this comparison changes in the magazines’ approach to CRM are identified and expert interviews with editors give further insight into the dynamic of the evolution CRM and the journalism industry are going through. Finally, the conclusion illuminates the effects this evolution has on CRM in journalism.
PICC Modulation Analysis
(2014)
This diploma thesis discusses interoperability problems between certified RFID readers and transponders based on the ISO/IEC14443 standardand the root cause for them.
The main goal is the definition of new test methodsand parameters that can supplement the existing test regime for such systems and allowthe identification of those problems beforehand.
Purpose: This study addresses issues of occupational mental health among nurses. Factors such as linking role, work and social factors, stress, burnout, depression, absenteeism and the intention of turnover, guides the research. The purpose of this research paper therefore looks forward to answer the question "How to measure the extent at which nurses experience symptoms or risk of depression through various factors such as individual or demographic factors, emotional exhaustion and stressful working situations?"
Design: Data were collected from 9 nurses working for major hospitals located in Germany, Baden-Württemberg (Mannheim and Heidelberg), Bremen, Ukraine and Ghana.
Methods: The design and method utilized in the qualitative and quantitative research methods is a survey, which consists of a questionnaire and biographical Interviews.
Questionnaire was used to collect data, which included demographic and job characte-ristics, job-related stress, emotional labor, and depressive symptoms The PHQ-9, serves to measure the depressive symptoms of the participants and serves as an instrument to back up the Interviews conducted. The questionnaire was evaluated with the SPSS version 21.0. Descriptive statistics, correlations, and frequency were used to analyze and evaluate the data.
Results: The study found out that all the participants who took part in this survey are depressed ranging from minimal to moderate depression. The questionnaire detected approximately 20% of the participants being minimal depressed, 40%, mild depressed and 30% moderate depressed. The composed questions targeted on factors like Occupational Stress and Work strain with factors as well as recognition and appreciation from patients and organization. 77, 80% admitted, they have no recognition and appreciation from colleagues and patients. 44,40% turned out to be very stressed up with
their daily work routine and the other 55,60% finds it only stressful .100% turned out to find Labor disturbances as a stress factor. All the participants are not pleased with their salary which leads to Job dissatisfaction.
Conclusion: The results show that it is necessary to implement programs for nurses to help reduce job-related stress, Preventive and suitable methods should be considered to reduce mental strain before depression manifest itself.
Clinical Relevance: Introducing programs that may help nurses and its organization is the work of Human resource management in nursing organization. Nursing administrators have to understand that, the rate at which nurses have to work and deal with other stressful situations might cause them to suffer depressive symptoms. In other to help this situation, they can aspire to enhance stressful work conditions, develop programs
that subdue job related stress and minimize the expectations of depressive symptoms.
The purpose of this study was to investigate the effects of provocative marketing strategies of different companies in the fashion industry in the first part. The thesis emphasizes on various strategies used by several firms. Furthermore it demonstrates the
different modes of provocation and also the process of a marketing strategy. The second part highlights the opportunities and risks of provocative marketing strategies based on American Apparel.
As widely discussed in literature spatial patterns of amino acids, so-called structural motifs, play an important role in protein function. The functional responsible part of a protein often lies in an evolutionary highly conserved spatial arrangement of only few amino acids, which are held in place tightly by the rest of the structure. In general, these motifs can mediate various functional interactions, such as DNA/RNA targeting and binding, ligand interactions, substrate catalysis, and stabilization of the protein structure.
Hence, characterizing and identifying such conserved structural motifs can contribute to understanding of structurefunction relationships in diverse protein families. Therefore and because of the rapidly increasing number of solved protein structures, it is highly desirable to identify, understand and moreover to search for structural scattered amino acid motifs. The aim of this work was the development and the implementation of a matching algorithm to search for such small structural motifs in large sets of target structures. Furthermore, motif matches were extensively analyzed, statistically assessed and functionally classified. Following a novel approach, hierarchical clustering was combined with functional classification and used to deduce evolutionary structure-function relationships. The proposed methods were combined and implemented to a feature-rich and easy-to-use command line software tool, which is freely available and contributes to the field of structural bioinformatic research.
Protein structures are essential elements in every biological system evolved on earth, where they function as stabilizing elements, signaltransducers or replication machin eries. They are consisting of linear-bonded amino acids, which determine the three-dimensional structure of the protein, whereas the structure in turn determines the function. The native and biological active structure ofa protein can be understood as the folding state of a polypeptide chain at the global minimum of free energy.
By means of protein energy profiling, which is an approach derived from statistical physics it is possible to assign a so called energy profile to a protein structure. Such an energy profile describes the local energetic interaction features of every amino acid within the structure and introduces an energetic point of view, instead of a structural or sequential onto proteins.
This work aims to give a perspective to the question of how we may gain pattern information out of energy profiles. The concrete subjects are energy-mapped Pfam family alignments and investigations on finding motifs or patterns indiscretizised energy profile segments.
Proteins are involved in almost every aspect of life, mediating a wide range of cellular tasks. The protein sequence dictates the spatial arrangement of the residues and thus ultimately the function of a rotein. Huge effort is put into cumbersome structure eludication experiments which obtain models describing the observed spatial conformation of a protein, enabling users to predict their function, to understand their mode of action or to design tailored drugs to cure disease caused by misfolded or misregulated proteins.
However, the result of structure determination experiments are merely models of reality, made under simplifying assumptions - sometimes containing major undetected errors. On the other hand, such experiments are resource demanding and they cannot supply the actual demand.
Thus, scientists are predicting the structure of proteins in silico, resulting in models that are even
more prone to error.
In consequence, the structure biologists search after a practicable definition of structure quality and over the last two decades several model quality assessment programs emerged, measuring the local and global quality of peculiar structures. Seven representatives were studied, regarding the paradigms they follow and the features they use to describe the quality of residues. Their predications were compared, showing that there is almost no common ground among the tools.
Is there a way to combine their statements anyway?
Finally, the accumulated knowledge was used to design a novel evaluation tool, addressing problems previously spotted. Thereby, high quality of its predication as well as superior usability was
key. The strategy was compared to existing approaches and evaluated on suitable datasets.
A number of real time PCR approaches have been published in the literature. In this thesis, the suitability of different real time PCR approaches using hydrolysis probes have been evaluated regarding PCR performance, cost effectiveness as well as handling. The effect of double-quenched probes as well as the impact of the increase of relative Flap endonuclease amount in quantitative real time PCR has been examined. In terms of genotyping a TaqMan™ assay, considered to be the gold-standard in this application, has been tested and compared to phosphorothioate modified probes, allele specific primers, SNAKE primers, an allele specific probe and primer assays as well as an assay using minor groove binder probes. Promising observations have been made in the case of double-quenched probes, phosphorothioate modified probes, SNAKE primers as well as minor groove binder probes.
The following thesis contains a detailed business plan of a formula student combustion racecar. This includes the evaluating of existing knowledge about the car combined with required information about the market and seed capital. Subsequently the already presented plan is described with the interpretation for future business plans. In this connection the acceptance of electro mobility shall be evaluated and first ideas for the presentation of an electric car shall be created.
Die vorliegende Arbeit befasst sich mit der Analyse der kritischen Erfolgsfaktoren für die Zulassung europäischer Industrieprodukte in Indien, anhand eines europäisch entwickelten und produzierten Produktes für die indische Rolling Stock Industrie. Die dabei berücksichtigen Themenschwerpunkte, die im Detail betrachtet sind über: Welche Standards werden derzeit in Indien bzw. in Europa offiziell für den Zulassungsprozess herangezogen? Aktuelle Situation erfassen. Vergleich der technischen Zulassung Standards zwischen IR (Indischen Railway) Standards und
The almost complete transcription of the human genome yield in a high number of transcripts, that do not encode proteins. However, the functional elucidation of especially long non cod-ing RNAs is still difficult. Secondary structure analysis is assumed to be a possible method to detect functional relationships of lncRNAs on a large scale, but it is still time consuming and error-prone. GRAPHCLUST, the currently most suitable clustering tool based on RNA secondary structure analysis, lacks mainly in an efficient method for the interpretation of its results. Hence, an independent and interactive RNA clustering interpretation tool was developed to allow visu-alisation and an efficient analysis of RNA clustering results.
This paper set out to determine what the effect of daily internet usage on a short attention span was and whether this had an effect on academic performance. As described briefly in the introduction this paper consisted of laying the groundwork through defining the relevant terminology, applying the methodology to the Hypotheses and making conclusive statements.
Two Hypotheses were presented to give the paper the aim. While Hypothesis 1 can be proven true through the two-step terminology applied, Hypothesis 2 does not stand up to the scrutiny. For lack of sufficient and specific evidence, the only conclusive statement that can be made regarding it is that it is untrue.
Approx. 80% of the population sample analysed were between the age of 19 – 30 which automatically reduces the analysis, extrapolations and scientific statements to a more specific age group. The other ages represented were almost all above, meaning that the findings could not accurately be applied to older age groups.
Nonetheless, the data collected was accurate and good be applied to prove Hypothesis 1, meaning that daily internet usage breeds and invites a short attention span. For lack of a fitting data collection method, physcial, social, mental factors along with motivation of an individual make up his academic performance. These were factors that could not be taken into consideration.
Conclusively, the author predicts that a present internet connection coupled with the growing popularity of digital technology attention spans will contin ue to stay as short as they are. Individuals will find ways to direct their short attention span where it is needed and apply it as necessary.
Evolution of Game Music : a look at characteristic elements of music in video games across time
(2015)
Music in video games is a subject worth regarding. Nevertheless, it isn't totally explored yet. This thesis shows and explains characteristics every video game music has and explores them regarding the developments in the history of video games. The thesis contains information about video games that inspired the musical evolution of games or that contain music as key part, as well as information about technological advances that influenced the musical evolution.
The cultivation of mammalian cells in the third dimension has a great potential for a
wide application in regenerative medicine, pharmaceutical industry or cancer research.
An overview about actual 3-D cultivation techniques like hydrogels and porous scaffolds as well as their various materials and modifications is given in this thesis. Also different products and their implementation for a new application of 3-D cell
culture in a laboratory are described.
This Bachelor thesis deals with connected systems consisting of a multitude of similar electronic devices
(often referred to as agents) endowed with information processing abilities. It is required that these socalled multi-agent systems solve a certain task with a high reliability, while the individual components
are not able to solve the problem on their own in a satisfying manner. A central control unit can not or
shall not be used in such systems for a variety of different reasons: For example, a significant drawback of
a central control unit is the vulnerability of the system. If the central control unit fails, the whole system breaks down. Therefore, multi-agent systems require special algorithms enabling the agents to solve a
common, global problem in a suitable manner by local interaction only.
In this thesis distributed algorithms are investigated which can be used for distributed information pro-cessing and control of such multi-agent systems. In the first part of this work, it is assumed that each
agent posses a private information state about a common parameter of interest. The described consensus algorithm enables all agents to reach a system-wide identical information state by local information
exchanges only. Subsequently, it is considered the case that every agent has access to streaming data containing information about an a priori unknown parameter. The diffusion strategy described in the second
part enables the agents to estimate this parameter and to minimize a global cost function which depends
on it. Both algorithms are described in a general framework and can therefore be applied to a variety of
different problems. One application of these strategies, which is described in the third part of this work,
is the simulation of swarming behavior.
A variety of methods have been used to describe natural systems and cellular functions. Most use continuous systems with differential equations. Based upon the neighbourhood relations in graphs and the complex interactions in cellular automata a mathematical model was designed and implemented as an application user interface. This discrete approach called graph automata was utilised to simulate diffusion processes and chemical kinetics. The progression of diffusion in cellular environments was described and resulted in a discrepancy of 20% in comparison to experimental results. Different chemical kinetics were simulated and found to be as accurate as their continuous counterparts. The proposed model appears to be a highly scalable and modular
approach to simulate natural systems.
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The voluntary international blog VaultingNews exists for two years now. Meanwhile the
team grew and the costs increased. This thesis is a collection of tools, which can help
to improve the communication of the team members who are spread all over the world
and introduces monetization ideas where the focus lies on establishing an online fan
shop based in Germany. This chapter results in a check list which laws have to be
observed.
This thesis investigated the generation of laser induced periodic surface structures (LIPSS) using femtosecond laser irradiation at a central wavelength of 775 nm.
The metals stainless steel and copper as well as a semiconducting thin film, ITO on glass substrate were investigated. The impact of the processing parameters was studied for single and multiple pulse irradiation to determine the ablation threshold of the materials
and the different types of LIPSS. These observations allowed the optimisation of area structuring with regards to processing speed and LIPSS quality.
The feasibility of the LIPSS generation in dynamic, real time polarisation control was then explored. By using a fast response, liquid-crystal polarisation rotation device, the direction of the linear polarisation of the laser beam could be dynamically controlled and synchronised to the scanning during laser processing. As a result, a range of complex micro- and nano-scale patterns with orthogonal direction of LIPSS were created. The samples were analysed using optical and electron microscopy. The orientation of the LIPSS was determined also from detection of light diffracted by the LIPSS.
Finally, two applications of large area LIPSS patterning were demonstrated, information encoding on metals and periodic structuring of a thin film conducting oxide for solar cells.
This master’s thesis was written in cooperation with the Spanish company sí-internships. Developing an effective promotion strategy for this startup spending as little financial resources as possible is the main objective of this work. To do so an extensive research on the current internal, external and integral market situation follows. Building on the results of this analysis promotional objectives are being determined and a target audience chosen. Next a promotion strategy is being established.
The design of an interview model based on competencies arises from the need to have highly qualified people that contribute to the achievement of organizational objectives. It intendes to shape the department of human resources into a strategic area of the company. To achieve this, organizational competencies are defined, and guidelines for the elaboration of a portfolio of questions, as well as the design of a competency dictionary, are established. These serve as tools for the human resources processes of the company Visbal Moreno y Sucesores Ltd. Through this work, the importance of the human factor is exposed as part of the organizational strategy.
Thіs bachеlоr thеsіs was еxеcutеd fоr Іntеrpіpе cоmpany and іt cоncеntratеs оn іts busіnеss stratеgy оn іntеrnatіоnal markеts, еspеcіally оn Mіddlе Еastеrn pіpеs markеt. Chооsіng an іnapprоprіatе еntry busіnеss stratеgy can lеad tо sіgnіfіcant nеgatіvе cоnsеquеncеs, busіnеss stratеgy sеlеctіоn оn іntеrnatіоnal markеts іs оnе оf thе mоst crіtіcal dеcіsіоns іn іntеrnatіоnal tradе systеm. Thе thеоrеtіcal framеwоrk оf thе bachеlоr thеsіs іs prоvіdеd іn thе sеcоnd chaptеr, whіch was maіnly cоllеctеd by dеsktоp studyіng. Thе thеоry rеvіеw cоntaіns dеscrіptіоn оf varіоus fоrеіgn markеt stratеgіеs, mеthоds and mеchanіsms оf dеcіsіоn-makіng, lеvеls and typеs оf busіnеss еnvіrоnmеnt. A cоmbіnatіоn оf thеоrіеs іs adоptеd tо facіlіtatе thе prоcеss оf gathеrіng thе rеquеstеd іnfоrmatіоn. Thе thіrd chaptеr cоntaіns іnfоrmatіоn abоut Іntеrpіpе Cоmpany und іt´s еcоnоmіc actіvіty іn thе hоst cоuntry and abrоad. Gеnеral іnfоrmatіоn abоut Іntеrpіpе Cоmpany, іts currеnt pоsіtіоn, busіnеss dеvеlоpmеnt stratеgy fоr 2015-2016 yеars arе prеsеntеd. Thе sіtuatіоn оn thе pіpеs and whееls markеt іn Ukraіnе durіng thе pеrіоd 2014-2015 was analyzеd and оn accоunt оf thіs thе rеasоns оf dеclіnе іn prоfіts and salеs wеrе еducеd. Cоіncіdеntly thе pеnеtratіоn fоrms оf Іntеrpіpе Cоmpany tо fоrеіgn cоuntrіеs wеrе cоnsіdеrеd. Іn thіs rеgard thе mоst succеssful еntry fоrms arе suggеstеd tо bе accеptеd as thе maіn kеy stratеgy оf pеnеtratіоn tо thе іntеrnatіоnal markеt. Thе fоrth chaptеr prоvіdеs thе іnfоrmatіоn abоut thе cеrtaіn apprоach оf pеnеtratіоn оf Іntеrpіpе Cоmpany tо thе Mіddlе Еastеrn pіpе markеt. Thе purpоsе іs tо іncrеasе thе numbеr оf dеlіvеrіеs tо оіl and gas cоmpanіеs іn thіs rеgіоn and cоntіnuе еstablіshіng оf іts rеlatіоns wіth kеy agеnts and dіstrіbutоrs. Thе prоjеct aіms tо еlеvatе currеnt pоsіtіоn оf thе еntеrprіsе оn Mіddlе Еastеrn pіpеs markеt and adjust advantagеоus іntеrnatіоnal rеlatіоns fоr bоth cоuntеrparts. Data іs cоllеctеd frоm varіоus sоurcеs, іncludіng: bооks and jоurnals іn thе thеоrеtіcal framеwоrk, nеwspapеrs, cоmpany’s publіshеd rеpоrts, prеss rеlеasеs, catalоguеs, bullеtіns, brоchurеs, prеsеntatіоn, Іntеrnеt rеsоurcеs еtc. іn thе еmpіrіcal study.
The intention of this thesis is to examine the beneficial impact of renewable energies in general and biogas technologies in particular on socioeconomic status of people, by considering all applicable sides affecting its development as per political, cultural, environmental, and institutional means. As energy and development are very much correlative with each other, biogas technologies figure prominently as part of a decentralized, sustainable, renewable, energy network especially in rural areas of Nepal.
Cancer is one of the main causes of death in developed countries, and cancer treatment heavily depends on successful early detection and diagnosis. Tumor biomarkers are helpful for early diagnose. The goal of this discovery method is to identify genetic variations as well as changes in gene expression or activity that can be linked to a typical cancer state.
First, several cancer gene signaling pathways were introduced and then combined. 27 candidate genes were selected, through the analysis of several data sets in the GEO database, a few expression difference matrices were established. Those candidate genes were tested in the matrices and found five genes PLA1A, MMP14, CCND1, BIRC5 and MYC that have the potential to be tumor biomarkers. Two of these genes have been further discussed, PLA1A is a potential biomarker for prostate cancer, and MMP14 can be considered as a biomarker for NSC lung cancer.
Finally, the significance of this study and the potential value of the two genes are discussed, and the future research in this direction is a prospect.
The loss of photoreceptors is a major course for visual impairment and blindness with no cure currently established. Photoreceptor replacement into mouse models of retinal degeneration is currently investigated as a potential future therapy. To evaluate visual function in mice before and after treatment two vision-based behavioral tests (optomotor tracking and the light/dark box) were investigated including their feasibility to distinguish between rod and cone photoreceptor function. Both methods turned out to be an objective and reliable readout for vision ability in wildtype mice and mice with vision impairment due to retinal degeneration. The capability of the methods to assess slight vision improvements have to be further evaluated.
Therefore options for improvement of the established tests and an idea for a new test paradigm have been introduced.
Die vorliegende Diplomarbeit befasst sich mit der Analyse, Auswertung und Empfehlung einer Berechnungsmethode für die axiale Klemmkraft und Wellenmuttern-Anzugsmoment bei Hochgenauigkeits-Axial-Schrägkugellagern für Gewindetriebe. Des Weiteren wird der Einfluss der Klemmkraft bzw. WellenmutternAnzugsmomentes auf unterschiedliche Lagersätze und –anordnungen überprüft und Korrekturfaktoren dafür erarbeitet
Genetic sex determination of ancient DNA samples based on one simple mathematical algorithm, which considers the number of mapped reads on autosomal, X, and Y chromosomes. The algorithm is implemented in one command line tool - SiD. SiD is used to deter-mine the sex of 16 samples, which have been shotgun sequenced and captured with a 1240k panel.
Large bone defects are a major clinical problem affecting elderly disproportionally, particularly indeveloped countries where this population is the fastest growing. Current treatments include autologous and allogenous bone grafts, bone elongation with the Ilizarov technique, bone graft substitutes, and electrical stimulation. Each of these approaches enjoys varying degrees of success, however, each also has its associated problems and complications. A new, still experimental, treatment is Tissue Engineering that combines scaffolds, osteogenic stem cells and growth factors, and is showing encouraging early results in preclinical and initial clinical studies.
Electrical stimulation has been shown to enhance bone healing by promoting mesenchymal stem cell migration, proliferation, and differentiation. In the present study we combine Tissue Engineering with Electrical Stimulation and hypothesize that this combined approach will have a synergistic effect resulting in enhanced new bone formation. In our in vitro experiments we observed that the levels of electrical stimulation we tested had no cytotoxic effect, instead increased osteogenic differentiation, as determined by enhanced expression of the osteogenic marker, Alkaline Phosphatase. These findings support our hypothesis by demonstrating that in the tissue-engineering environment electrical stimulation promotes bone formation. The bioinformatics part of this project consisted of gene network analysis, identification of the top 10 osteogenic markers and analyzis of genegene interactions. We observed that in studies of stem cells from both human and rat the genes, BMPR1A, BMP5, TGFßR1, SMAD4, SMAD2, BMP4, BMP7, RUNX3, and CDKN1A, are associated with osteogenesis and interact with each other. We observed a total of 31 interactions for human and 29 interactions for rat stem cells. While this approach needs to be proven experimentally, we believed that these in vitro and in silico analyses could compliment each other and in doing so contribute to the field of bone healing research.
Classification of time series has received an important amount of interest over the past years due to many real-life applications, such as environmental modeling, speech recognition, and computer vision.
In my thesis, I focus on classification of time series by LVQ classifiers. To learn a classifiers, we need a training set. In our case, every data point in the training set contains a sequence (an ordered set) of feature vectors. Thus, the first task is to construct a new feature vector (or matrix) for each sequence.
Inspired by [2], I use Hankel matrices to construct the new feature vectors. This choice comes from a basic assumption that each time series is generated by a single or a set of unknown Linear Time Invariant (LTI) systems.
After generating new feature vectors by Hankel matrices, I use two approaches to learn a classifier: Generalized Learning Vector Quntization (GLVQ) and Median variant of Generalized Learning Vector Quantization (mGLVQ).
Stability of control systems is one of the central subjects in control theory. The classical asymptotic stability theorem states that the norm of the residual between the state trajectory and the equilibrium is zero in limit. Unfortunately, it does not in general allow computing a concrete rate of convergence particularly due to algorithmic uncertainty which is related to numerical imperfections of floating-point arithmetic. This work proposes to revisit the asymptotic stability theory with the aim of computation of convergence rates using constructive analysis which is a mathematical tool that realizes equivalence between certain theorems and computation algorithms. Consequently, it also offers a framework which allows controlling numerical imperfections in a coherent and formal way. The overall goal of the current study also matches with the trend of introducing formal verification tools into the control theory. Besides existing approaches, constructive analysis, suggested within this work, can also be considered for formal verification of control systems. A computational example is provided that demonstrates extraction of a convergence certificate for example dynamical systems.
It is possible to obtain a common updating rule for k-means and Neural Gas algorithms by using a generalized Expectation Maximization method. This result is used to derive two variants of these methods. The use of a similarity measure, specifically the gaussian function, provides another clustering alternative to the before mentioned methods. The main benefit of using the gaussian function is that it inherently looks for a common cluster center for similar data points (depending on the value of the parameter s ). In different experiments we report similar behaviour of batch and proposed variants. Also we show some useful results for the “alternative” similarity method, specifically when there is no clue about the number of clusters in the data sets.
This thesis was written in order to prove the expediency of startup ecosystem support and to develop practical recommendations for Belarusian government based on the analysis of successful practices in the U.S. and Lithuania.
It covers the essence of a “startup company” and a “startup ecosystem” as well as provides the analysis of socioeconomic impact of startup companies with particular focus on job creation. It sheds light on the best startup support policies in the U.S., where most prominent startup ecosystems are operating, and Lithuania as a country with similar to Belarusian preconditions and a rapidly
developing ecosystem. Furthermore, this paper deals with Belarus‘s peculiarities regarding fostering startup ecosystem growth. It assesses recent economic development of Belarusian IT sector and gives an insight into its competitive advantages and challenges.
The subsequent paper is based on internet research using articles, presentations, reports and studies, websites and official legal documents.
The endogen steroid hormone 17b-estradiol is a central player in a wide range of physiologic, behavioral processes and diseases in vertebrates. As a consequence, it is a main target for molecular design and drug discovery efforts in medicine and environmental sciences, which requires in-depth knowledge of protein-ligand binding processes. This work develops a bioinformatic framework based on local and global structure similarity for the characterization of E2-protein interactions in all 35 publicly available three-dimensional structures of estradiol-protein complexes. Subsequently, it uses gained data to identify four geometrically conserved estradiol binding residue motifs, against which the Protein Data Bank is queried. As result of this database query, 15 hits present in seven protein structures are found. Five of these structures do not contain E2 as ligand and had thus not been included in this work’s initial data set. One of these newly detected structures is structurally and functionally dissimilar, as well as evolutionarily distant from all other proteins analyzed in this work. Nevertheless, the ability of this protein to actually bind estradiol must be further analyzed. Finally, geometrically conserved E2-protein interactions are identified and a new research direction using these conserved interaction ensembles for the detection of novel estradiol targets is proposed.
Going green, environmental protection, eco-friendliness, sustainability or sustainable development have become frequent terms in everyone’s life. The negative impact of human activities, causing increased environmental pollution and decline, is a matter of dire concern nowadays. In the last few decades greater attention has been payed towards these issues. Understanding society´s new concerns, increasingly more companies have begun to modify their behaviours toward a more eco-friendly and responsible one. The term green marketing is an emerging area of interest, and is a tool of modern marketing used by companies in various industries. It is a full-service marketing strategy that includes green marketing plan development, sustainable auditing and planning, branding, design, and communication. An effective, authentic and transparent green presentation of a company provides a chance to successfully assert on the market, communicate core company values and build long-term customer relations. The young and innovative company SWOX Surf Protection, which entered the market with a long-lasting waterproof sunscreen particular designed for surfers and snowboarders, wants to foster growth by expanding their existing target group to a broader segment comprising all outdoor activists. Moreover, the brand strives to become the leading sunscreen manufacturer for outdoor sports and wants to position itself as a lifestyle brand. In 2016 the company started to produce “greener” sunscreen tubes with an imminent launch at hand. Due to the fact that especially surfers, snowboarders and outdoor activists are in close contact with nature and spend a lot of time in the sun, it is assumed that they have particular interest in making use of sunscreen on a healthrelated aspect, while at the same time showing increased commitment towards environmental protection. In this context, it is assumed that a holistic green and organic sunscreen could provide added values. This paper intends to examine whether green marketing could be a relevant strategy for SWOX Surf Protection to differentiate themselves from their competitors, attract potential customers, build long-term customer relations - and as a result position itself as a successful sunscreen lifestyle brand in the market. This will be verified through comprehensive literature review and detailed market research.
Brassica oleracea like all crucifers plants have a defense mechanism against natural enemies, which are chemical compounds formed form the enzymatic degradation of glucosinolates. In the presence of epithiospecifier proteins (ESP), the hydrolysis of glucosinolates will form epithionitriles or nitriles depending on the glucosinolate structure, This research proved that three predicted sequences (ESP) taken from NCBI database has a role in the enzymatic hydrolysis of glucosinolates in Brassica oleracea.
The following is a description and outline of the work done at the Cornell Lab of Ornithology developing Nation Feathers VR, a virtual reality game for learning about bird calls and songs. The goal was to develop a game which is intuitive, educational and entertaining. Furthermore, the software needed to be structured in a way that allows for feasible future expansion. This required careful data saving and retrieval. The game gives the player an opportunity to learn and apply that knowledge, all while maintaining a shorter runtime in order to reduce the total time spent in the virtual world. This is meant to prevent any discomfort to the player that may result from extended use of the VR headset.
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Massive multiple-input multiple-output (MIMO), eine Technik bei der die Basisstation einer Mobilfunkzelle mit einer großen Anzahl an Antennen ausgestattet ist, wird derzeit als eine vielversprechende Schlüsseltechnologie zur Erfüllung der Anforderungen zukünftiger drahtloser Kommunikationsnetze der fünften Generation betrachtet. Die zuversichtlichen Angaben über die Leistung solcher Systeme beruht allerdings auf einer theoretischen, bisher kaum praktisch verizierten Annahme, dass die drahtlosen Übertragungskanäle verschiedener Nutzer aufgrund der hohen Anzahl an Antennen voneinander unabhängig sind. Das heißt, dass sogenannte günstige Übertragungsbedingungen herrschen. Die vorliegende Masterarbeit untersucht diese neuartigen Systeme unter zwei verschiedenen Perspektiven.
Im ersten Teil dieser Arbeit wird der Einfluss von realistischen Übertragungsbedingungen auf die Performance von massive MIMO Systemen evaluiert. Dazu werden entsprechende numerische Systemsimulationen durchgeführt und mit den Ergebnissen von praktischen massive MIMO Messkampagnen verglichen.
Die Untersuchungen ergeben, dass die sogenannten günstigen Übertragungsbedingungen in realistischen Umgebungen nur bedingt beobachtet werden können. Daher führen traditionelle Kanalmodelle zu einer ungenauen Abschätzung der Leistung von praktischen massive MIMO Systemen. Um diesem Problem zu begegnen, wird deshalb eine neuartige Parametrisierung des traditionellen Kronecker-Modells vorgeschlagen, sodass relevante Kenngrößen realistischer Kanäle mit diesem Modell präzise widergespiegelt werden.
Anschließend folgt eine Untersuchung verschiedener Methoden zur Kanalschätzung in massive MIMO Systemen unter den verschiedenen Kanalmodellen mittels numerischer Simulationen. Die Experimente zeigen auf, dass Schätzmethoden, welche speziell für massive MIMO unter der Annahme von günstigen Übertragungsbedinungen hergeleitet wurden, eine signifikante Leistungsminderung unter realistischen Kanalmodellen erfahren.
Im zweiten Teil dieser Arbeit liegt der Fokus auf der Anwendung von massive MIMO Systemen in sogenannten Internet of Things (IoT) Netzwerken. Die typischerweise hohe Anzahl an aktiven IoT-Geräten macht die Anwendung von effizienten Scheduling-Algorithmen notwendig. Daher wird ein Downlink-Scheduling-Algorithmus präsentiert, welcher sich die Eigenschaften von massive MIMO Systemen und die typischen Anforderungen an die Datenraten von IoT-Geräten zunutze macht. Im Speziellen wird vorgeschlagen, die IoT-Nutzer in Gruppen aufzuteilen und die verschiedenen Gruppen nacheinander zu versorgen. Die Gruppengröße wird dabei mit Hilfe asymptotischer Eigenschaften von massive MIMO Systemen hergeleitet.
Um die Gruppenmitglieder zu selektieren, wird eine modifizierte Version des populären Semi-Orthogonal-User-Selection (SUS) Algorithmus vorgeschlagen. Die anschließend durchgeführten numerischen Simulationen bestätigen, dass die modifizierte Version von SUS die Nachteile des originalen Algorithmus eliminiert, was wiederum zu verbesserten Datenraten in dem betrachteten System führt.
This master thesis was developed based on public information about Linde AG. It analyzed and evaluated macroeconomic factors influencing the pеrformance of the company. Microeconomic and macroeconomic indicators play the central role for the financial management of each global company. Thus, performance measurement is important for understanding the vаlue and extent of the environment. The study of the thesis aims at estimating the extent to which a company may opеrate on the global market and what factors contribute to its performance the most.
Firstly, the thesis examines theoretical background based on the previous researches. It defines the specific macroeconomic and microeconomic factors and their role in the company’s performance. Afterwards the thesis analyses Linde AG activities on domestic and foreign markets. The present structure, the current position in the markets and financial indicators are analyzed. The correlation and regression analysis were developed with the aim to find the links between the company’s performance and the macroeconomic environment. It is believed that inflation, exchange and interest rates as well as stock market index have a significant influence on the Linde’s performance.
The results showed that the indicators of inflation rate and stock market index play a significant role in the Linde’s performance. Thus, when it comes to exchanging rates, more data needs to be evaluated in order to derive concrete conclusions.
Success story DAB in the UK
(2017)
The popularity of digital audio broadcasting in different countries can be explained mainly by means of historical development. In this work, the general technical conditions are explained and the mode of operation is explained. In addition, advantages, disadvantages and alternatives are presented. After that, the development of the digital radio in Germany and the UK is compared with the current situation in order to show how the differences have led to a different distribution and acceptance of the medium.
Obesity is a major public health issue in many countries and its development leads to many severe conditions. Adipose tissue (AT) simply called fat, in males visceral adipose tissues (VAT) are dominant. Estrogens play an important role in many pathological processes.
In this study, one of the subtypes of the estrogen receptor ER-beta is activated using KB (Specific ligand) treatment on VAT.
In this study, I investigated the metabolism effectof KB treatment on VAT using bioinformatics methods.
In this thesis study, I applied several bioinformatics methods such as differential expression gene analysis, pathway analysis, RNA splicing analysis and SNPs callings to make the prediction of the effect of KB treatment on VAT. A list of candidate genes, pathways and SNPs were identified in this study, which could provide some clues to reveal the genetic mechanism underlying the KB treatment effect. The results of my study show that the KB treatment on VAT has caused significant effect.
This thesis proposes a solution to the practical problem of supervising relatively basic mechanic processes in robotics by means of computervision. Supervision happens by comparing the tracked movement with a known, ideal recording of the movement that acts as a model.
First, this thesis analyzes possible approaches to the problem regarding data structures and representation, ways of extracting the data from the recording and ways to compare the data sets of two recordings. Then, a specific solution is implemented in C++ and explained.
The computer based calculation of the sound insulation in between dwellings or the analysis of the transmission in a building are common use in practice of a building acoustic engineer. With the release of the revised DIN 4109 in July 2016 a whole new calculation model was introduced to the German users of this standard. The calculation model and its input data now need to be included into existing calculation software, such as the software SONarchitect ISO of the Spanish developers Sound of Numbers. For this cause this thesis compares the input parameter and the airborne and impact sound transmission of the DIN 4109:2016-07 and European standard EN 12354:2000. With the help of this comparison it now is possible to declare all necessary parameter and calculation procedures for the calculation of the airborne and impact sound insulation between dwellings.
The object of the thesis is the material and information flows in the production systems of enterprises, in particular, of LLC "Kolibri".
As a subject of thesis, the improvement of the management of material and related information flows of the company LLC "Kolibri" was chosen.
The purpose of the thesis is theoretical substantiation and development of practical recommendations for the effective management of the flows of material and information resources of the enterprise on the principles of logistics.
The Blockchain is a technology which has the capabilities to change the way, the world operates. As promising as this may be, there are still many challenges which do not exist or are way simpler to solve in conventional software solutions. Services which are offered over the blockchain suffer from so called Block-confirmation-times where the customer simply has to wait till the transaction is confirmed. In this paper possible solutions to that problem will be examined and challenges that arise from the specific criteria of the Ethereum Blockchain will be analyzed.
In the context of globalization and the internationalization of international markets, mergers and acquisitions are becoming increasingly important for transnational corporations and national economies of countries as a form of internationalization, integration and the way to attract foreign investment. In the framework of this paper, the theoretical aspects of mergers and acquisitions have been analyzed, and the experience of Germany, China and Russia in attracting investments through mergers and acquisitions has been examined, and the success of this method for each country has been assessed.
This bachelor thesis examines two main topics: Corporate Social Responsibility and Corporate Philanthropy as an integral part of it. It was written in order to prove the high importance of business philanthropy in today’s global market and to encourage companies to strengthen their CSR policy so as to contribute to the resolution of social problems. This paper reviews the theoretical framework of CSR, its evolution, types and theories relating to Corporate Philanthropy. Also it represents a comparative analysis of successful practices of corporate philanthropy in pharmaceutical and other global industries predominantly in Europe and USA. This work underlines competitive advantages and important socio-economic impact of CP and suggest recommendations for companies in developing their CSR activities. The subsequent paper is based on internet research using articles, presentations, reports and studies, websites and official legal documents.
This thesis focuses on the introduction of a process for the fracture toughness testing of epoxy resin systems, in the light of the linear elastic fracture mechanic approach. Based on the requirements of ISO 13586, SENB-specimen were designed and especially the precracking process was analysed and the tapping process was optimized by designing and testing a drop-weight device. After successful validating the test process using specimen made of Araldite LY556, the in uence of GNP loading on the fracture toughness was analysed. The pure epoxy showed a KIc of 0.73 MPap
m, being perfectly in line with the manufacturers datasheet. A peak in fracture toughness of 0.83 MPap
m was archived at 1 wt% and a loading rate of 10 mm/min, showing a decreasing trend as the loading is increased further. As the loading rate is increased, the fracture toughness reduces slightly for 0.5 wt% and 2 wt% GNP, but
drops signicantly for 1 wt% GNP obliterating the peak. The load vs. displacement curves showed quasi-brittle material behaviour. The fracture surfaces were analysed using SEM and while the neat resin did not show any features, did the reinforced samples show pattern of crack pinning in connection with bridging and pull-out. The resulting improvement is less signicant as observed by other researchers for larger GNPs. This is in line with the general idea, that small particles are not able to yield as high improvements, but the signicant decrease for higher loading rates is not observed or described so far. It is suspected that tests at lower loading rates (e.g. 1 or 0.5 mm/min) show an even higher fracture toughness.
Aminoacyl-tRNA synthetases (aaRSs) are key enzymes in the process of protein biosynthesis, charging tRNA molecules with their corresponding amino acid. Whereas adenosine phosphate fixation is common to all aaRSs, recognition of the respective amino acid to ensure correct translation poses a complex task, which is still not understood to its full extent. Using all aaRS structures in the Protein Data Bank (PDB), this thesis reveals further details about the specificitydetermining interactions of each aaRS. Moreover, inspection of the similarities between these enzymes using the structure-derived interaction data reinforces the sequence-based evolutionary trace of aaRSs to a certain degree: The concurrent development of two distinct Classes of aaRS is apparent at functional level, and previously determined evolutionary subclasses coincide altogether with specific aminoacyl recognition in each aaRS Type. Still, discrimination of amino acids in aaRSs involves a multitude of further relevant mechanisms. Eventually, analysis of specificity-relevant binding site interactions sheds light on how aaRS evolved to distinguish different amino acids.
This study presents an analysis of the coverage made by the journals El País (Spain), Folha de S. Paulo (Brazil) and Süddeutsche Zeitung (Germany) about the protests in Brazil against the 2013 Confederations Cup and the 2014 FIFA World Cup to establish a comparison between them and see which topics were emphasized by the newspapers and which tone they use in their reporting. Based on the research questions, four categories were developed for the analysis of the journals: article structure; topic of the article; actors/group of persons and tone of the reporting, all of them composed by several subcategories. It was concluded that the themes highlighted by the European newspapers were different from those stressed on the Brazilian diary. Nonetheless, all the reviewed newspapers made a neutral coverage of the protests.
In this work, the task is to cluster microarray gene expression data of the cyanobacterium Nostoc PCC 7120 for detection of messenger RNA (mRNA) degradation patterns. Searched are characteristic patterns of degradation which are caused by specific enzymes (ribonucleases) allowing a further biological investigation regarding biochemical mechanisms. The mRNA degradation is part of the regulation of gene expression because it regulates the amount and longevity of mRNA, which is available for translation into proteins. A particular class of RNA degrading enzymes are exoribonucleases which degrade the molecule from its ends, whereby a degradation from the 5’ end, the 3’ end or from both ends is theoretically possible.
In this investigation, the information about exoribonucleolytic degradation is given in a microarray data set containing gene expression values of 1,251 genes. The data set provides gene expression vectors containing the expression values of up to ten short distinct sections of a gene ordered from the genes 5’ end to its 3’ end. For each gene, expression vectors are available for both nitrogen fixing and non-nitrogen fixing conditions, which have to be considered separately due to biological reasons. Accordingly, after filtering and preprocessing, two datasets for clustering are obtained consisting of 133 ten-dimensional expression vectors. The similarity of the expression vectors is judged by a newly correlation based similarity measure and compared with the results obtained by use of the Euclidean distance. A non-linear transformation of the correlations was applied to obtain a dissimilarity measure. By choice of parameters within this transformation a user specific differentiation between negative and positive correlated gene expression vectors and an adequate adjustment regarding the noise level of gene expression values is possible.
Clustering was performed using Affinity Propagation (AP). The number of clusters obtained by AP depends on the so-called self-similarity for the data vectors. This dependence was used to identify stable cluster solutions by self-similarity control. To evaluate the clustering results, Median Fuzzy c-Means (M-FCM) was used. Further, several cluster validity measures are applied and visual inspections by t-distributed Stochastic Neighbor Embedding (t-SNE) as well as cluster visualization are provided for mathematical interpretation analysis of clusters.
To validate the clustering results biologically, the found data structure is checked for biological adequacy. A deeper investigation into the mechanisms behind mRNA-degradation was achieved by use of a RNA-Seq data set. Contained 40 (base pair) bp long reads for non-nitrogen fixing and nitrogen fixing conditions were assembled using bacteria-specific ab-initio assembly of Rockhopper. Thus, mRNA (transcript)-sequences of the clustered genes are obtained. A further investigation of the untranslated regions (UTRs) is performed here due to the assumption that exoribonucleases recognize specific transcript-sequences outside of the annotated gene regions as their binding sites. These UTRs need to be analyzed regarding sequence similarity using motif-finding algorithms.
kein Abstract vorhanden
Path decomposition of a graph has received an important amount of interest over the past decades because of its applications in algorithmic graph theory and in real life problems. For the computation of a path decomposition of small width, we use different heuritics approaches. One of the most useful method is by Bodlaender and Kloks. In this thesis, we focus on the computation, applications, transformation and approximation of a path decomposition of small width.
It is easy to convert a path decomposition in to nice path decomposition with same width, which is more convinent to use to find the graph parameters like independent sets, chromatic polynomials etc. Inspired by [28], we find an algorithm to compute the chromatic polynomial of a graph via nice path decomposition with small width.
In this master thesis, we define a new bivariate polynomial which we call the defensive alliance polynomial and denote it by da(G; x; y). It is a generalization of the alliance polynomial and the strong alliance polynomial. We show the relation between da(G; x; y) and the alliance, the strong alliance, the induced connected subgraph polynomials as well as the cut vertex sets polynomial. We investigate information encoded about G in da(G; x; y). We discuss the defensive alliance polynomial for the path graphs, the cycle graphs, the star graphs, the double star graphs, the complete graphs, the complete bipartite graphs, the regular graphs, the wheel graphs, the open wheel graphs, the friendship graphs, the triangular book graphs and the quadrilateral book graphs. Also, we prove that the above classes of graphs are characterized by its defensive alliance polynomial. We present the defensive alliance polynomial of the graph formed of attaching a vertex to a complete graph. We show two pairs of graphs which are not characterized by the alliance polynomial but characterized by the defensive alliance polynomial.
Also, we present three notes on results in the literature. The first one is improving a bound and the other two are counterexamples.
In the following study we evaluated capabilities of how a simple autoencoder can be used to trainGeneralized Learning Vector Quantization classifier. Specifically, we proved that the bottlenecks of an autoencoder serve as an "information filter" which tries to best represent the desired output in that particular layer in the statistical sense of mutual information.
Autoencoder model was trained for purely unsupervised task and leveraged the advantages by learning feature representations. As a result, the model got the significant value of the accuracy. Implementation and tuning of the model was carried out using Tensor Flow [1].
An extra study has been dedicated to improve traditional GLVQ algorithm taken from sklearn-lvg [2] using the bottleneck from an autoencoder.
The study has revealed potential of bottlenecks of an autoencoder as pre-processing tool in improving the accuracy of GLVQ. Specifically, the model was capable to identify 75% improvements of accuracy in GLVQ comparing to original one, which has about 62%. Consequently, the research exposed the need for further improvement of the model in the present problem case.
Community acquired pneumonia (CAP) is a very common, yet infectious and sometimes lethal disease. Therefor, this disease is connected to high costs of diagnosis and treatment. To actually reduce the costs for health care in this matter, diagnosis and treatment must get cheaper to conduct with no loss in predictive accuracy. One effective way in doing so would be the identification of easy detectable and highly specific transcriptomic markers, which would reduce the amount of work required for laboratory tests by possibly enhanced diagnosis capability.
Transcriptomic whole blood data, derived from the PROGRESS study was combined with several documented features like age, smoking status or the SOFA score. The analysis pipeline included processing by self organizing maps for dimensionality and noise reduction, as well as diffusion pseudotime (DPT). Pseudotime enabled modelling a disease run of CAP, where each sample represented a state/time in the modelled run. Both methods combined resulted in a proposed disease run of CAP, described by 1476 marker genes. The additional conduction of a geneset analysis also provided information about the immune related functions of these marker genes.
In this work, we discuss the key role that “conflict minerals” (Gold, Coltan, Cobalt, Tin, Tungsten) play in global supply chains and high-technology industries, and the issues surrounding their extraction and trade in origin
countries, particularly in the African Congo Basin and the Great Lakes Region. We discuss ongoing international efforts to combat violence, child labour and human rights violations at mineral extraction areas, particularly in the Democratic Republic of the Congo (DRC), where very large mineral reserves have been discovered. We present the OECD Due Diligence Guidance for Responsible Supply Chains of Minerals from Conflict-Affected and High-Risk Areas, and the
GOTS MineralTrace mineral proof-of-origin and trade chain certification solution developed by ibes AG in Germany, which automates and simplifies the implementation of the OECD Guidance. We discuss a pilot project in DRC involving the GOTS GoldTrace application, based on the MineralTrace platform. We point out MineralTrace’s benefits and its limitations. We analyse possible solutions to said limitations, including an analysis of blockchain-based transactional information exchange and record keeping systems, and finally we propose a new MineralTrace Application Programming Interface (API) that solves current limitations, introduces configuration flexibility for client applications, introduces workflow flexibility to adapt MineralTrace to any country or region, and simplifies data export functionality.
Soft Learning Vector Quantisation (SLVQ) andRobust Soft Learning Vector Quantisation (RSLVQ) are supervised data classification methods, that have been applied successfully to real world classification problems. The performance of SLVQ and RSLVQ, however, reduces, when they are applied tomore complicated classification problems. In this thesis, we have introducedmodi-fications to SLVQand RSLVQ, in order to havemore capable versions of them. A few possibilities to modify SLVQ and RSLVQ are considered, some of them are not successful enough and they have been included for the sake of completeness. The fruits of the thesis are plenty, including Tangent Soft Learning Vector Quantisation-Strong (TSLVQ-S), together with its more stable version Tangent Robust Soft Learning Vector Quantisation-Strong (TRSLVQ-S), Attraction Soft Learning Vector Quantisation (ASLVQ) and Grassmannian Soft Learning Vector Quantisation (GSLVQ).