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Sensor fusion is an important and crucial topic in many industrial applications. One of the challenging problems is to find an appropriate sensor combination for the dedicated application or to weight their information adequately. In our contribution, we focus on the application of the sensor fusion concept together with the reference to the distance-based learning for object classification purposes. The developed machine learning model has a bi-functional architecture, which learns on the one side the discrimination of the data regarding their classes and, on the other side, the importance of the single signals, i.e., the contribution of each sensor to the decision. We show that the resulting bi-functional model is interpretative, sparse, and simple to integrate in many standard artificial neural networks.
The study “Proteomic and systems biological database analysis of changed proteins from rat brain tissue after diving “ is about system biological testing of proteomic data obtained by rat brain after experimental diving in a pressure chamber. Basically, brain tissue from animal decompression sickness (DCS) was analyzed by mass spectrometry and has given two larger sets of modified proteins. Thereupon, the resulting up- and down-regulated proteins wereidentified and later compared by means of systems of biological databases, in this case GeneGo MetaCoreTM, in order to find similar or various affected cell biological signaling pathways when two different mass-spectrometry methods were compared.
Evolution of Game Music : a look at characteristic elements of music in video games across time
(2015)
Music in video games is a subject worth regarding. Nevertheless, it isn't totally explored yet. This thesis shows and explains characteristics every video game music has and explores them regarding the developments in the history of video games. The thesis contains information about video games that inspired the musical evolution of games or that contain music as key part, as well as information about technological advances that influenced the musical evolution.
Community acquired pneumonia (CAP) is a very common, yet infectious and sometimes lethal disease. Therefor, this disease is connected to high costs of diagnosis and treatment. To actually reduce the costs for health care in this matter, diagnosis and treatment must get cheaper to conduct with no loss in predictive accuracy. One effective way in doing so would be the identification of easy detectable and highly specific transcriptomic markers, which would reduce the amount of work required for laboratory tests by possibly enhanced diagnosis capability.
Transcriptomic whole blood data, derived from the PROGRESS study was combined with several documented features like age, smoking status or the SOFA score. The analysis pipeline included processing by self organizing maps for dimensionality and noise reduction, as well as diffusion pseudotime (DPT). Pseudotime enabled modelling a disease run of CAP, where each sample represented a state/time in the modelled run. Both methods combined resulted in a proposed disease run of CAP, described by 1476 marker genes. The additional conduction of a geneset analysis also provided information about the immune related functions of these marker genes.
Decentralizing Smart Energy Markets - tamper-proof-documentation of flexibility market processes
(2020)
The evolving granularity and structural decentralization of the energy system leads to a need for new tools for the efficient operation of electricity grids. Local Flexibility Markets (or "Smart Markets") provide platform concepts for market based congestion management. In this context there is a distinct need for a secure, reliable and tamper-resistant market design which requires transparent and independent monitoring of platform operation. Within the following paper different concepts for blockchain-based documentation of relevant processes on the proposed market platform are described. On this basis potential technical realizations are discussed. Finally, the implementation of one setup using Merkle tree operations is presented by using open source libraries.
In the context of globalization and the internationalization of international markets, mergers and acquisitions are becoming increasingly important for transnational corporations and national economies of countries as a form of internationalization, integration and the way to attract foreign investment. In the framework of this paper, the theoretical aspects of mergers and acquisitions have been analyzed, and the experience of Germany, China and Russia in attracting investments through mergers and acquisitions has been examined, and the success of this method for each country has been assessed.
This Master Thesis covers two main Topics: Sharing Economy and Risk Management and combines them in frames of this paper in order to provide a methodology (Uber was chosen as an example) of how a risk management process may be applied to a Sharing Economy business, as well as which types of risks are of special relevance for those types of businesses.
Differentiation is ubiquitous in the field of mathematics and especially in the field of Machine learning for calculations in gradient-based models. Calculating gradients might be complex and require handling multiple variables. Supervised Learning Vector Quantization models, which are used for classification tasks, also use the Stochastic Gradient Descent method for optimizing their cost functions. There are various methods to calculate these gradients or derivatives, namely Manual Differentiation, Numeric Differentiation, Symbolic Differentiation, and Automatic Differentiation. In this thesis, we evaluate each of the methods mentioned earlier for calculating derivatives and also compare the use of these methods for the variants of Generalized Learning Vector Quantization algorithms.
Over recent years, Maximal Extractable Value (MEV) has gained significant importance within the decentralized finance (DeFi) ecosystem. Remarkably, within just two years of its emergence, MEV has seen an extraction of approximately 600 million USD - a phenomenon that has sparked concerns regarding potential threats to blockchain stability.
With growing interest in the Ethereum network and the growing DeFi sector, research surrounding MEV has substantially increased. This work aims to offer a comprehensive understanding of MEV. Additionally, this research quantifies the largest types of MEV (Arbitrage, Sandwich and Liquidations) from March 2022 to March 2023. The data are then compared to other sources, revealing a general upward trend, with a particularly noticeable increase in Sandwich Attacks.
This thesis aims to research the platform YouTube and whether “being a YouTuber” qualifies as a profession or not and what leads to this. The author combines existing scientific data and information provided by YouTubers doing this as a job and uses the compilation method. The author merges that material and uses it to create a bachelor thesis that covers both the theoretical and practical approach. The aim was to find out if there is a success recipe that can be followed that leads to views and clicks which are essential for the profession as a YouTuber. To do this, the author created two channels to see how the factors mentioned in this thesis are applied and if the approach leads to success. The findings of this thesis showed, that although the profession of a YouTuber can be classified as a job, it needs to be viewed differently from commonly known and in society accepted careers. Becoming a YouTuber and making money from this business, therefore, cannot be guaranteed.
In this work, a transgenic zebrafish line that expresses the fluorophore dsRed under the endogenous zebrafish cochlin promotor is supposed to be established, using the CRISPR/Cas9 system. dsRed was cloned into a pBluescript vector, followed by the cloning of the cochlin locus into this vector. This bait construct was then supposed to be micro injected into wild type AB zebrafish embryos. The micro injection of Cas9 mRNA, single guide RNA and a bait construct was practiced with the tyrosinase gene, which was disrupted using CRISPR/Cas9.
The digital transformation of higher education demands effective and efficient methods for learning support and assessment of learning processes. This paper relates learning support and assessment to each other in the context of learning management systems. It refers to previous studies carried out in multiple introductory economic courses of the University of Applied Sciences Mittweida which examine possible connections between the use of digital tests and learning success, investigate student’s acceptance and self-perceived learning success with respect to the webbased portion of a blended course and a purely online based course. Based on a survey (n = 71) and a quantitative analysis (n = 214) with logging and exam assessment data, the previous work shows that students approached the web-based course portion with rather reserved attitudes. Still, they perceived the individual course elements, namely videos, podcasts, interactive worksheets, online tests, and a comprehensive PDF file to be beneficial to their learning experience. Especially we could indicate a positive correlation between the points students achieved in the online tests and the exam results.
The set of transactions that occurs on the public ledger of an Ethereum network in a specific time frame can be represented as a directed graph, with vertices representing addresses and an edge indicating the interaction between two addresses.
While there exists preliminary research on analyzing an Ethereum network by the means of graph analysis, most existing work is focused on either the public Ethereum Mainnet or on analyzing the different semantic transaction layers using
static graph analysis in order to carve out the different network properties (such as interconnectivity, degrees of centrality, etc.) needed to characterize a blockchain network. By analyzing the consortium-run bloxberg Proof-of-Authority (PoA) Ethereum network, we show that we can identify suspicious and potentially malicious behaviour of network participants by employing statistical graph analysis. We thereby show that it is possible to identify the potentially malicious
exploitation of an unmetered and weakly secured blockchain network resource. In addition, we show that Temporal Network Analysis is a promising technique to identify the occurrence of anomalies in a PoA Ethereum network.
We investigate the folding and thermodynamic stability of a tertiary contact of baker's yeast ribosomal ribonucleic acid (rRNA), which is supposed to be essential for the maturation process of ribosomes in eukaryotes at lower temperatures1. Ribosomes are cellular machines essential for all living organisms. RNA is at the center of these machines and responsible for translation of genetic information into proteins2,3. Only recently, the rRNA tertiary contact of interest was discovered in Zurich by the research group of Vikram Govind Panse. Gerhardy et al.1 showed in vitro that within the 60s-preribosome under defined metal ion concentrations the tertiary contact become visible between a GAAA-tetraloop and a kissing loop motif. Our aim is now to understand this RNA structure, especially the formation of the rRNA tertiary contact, in terms of thermodynamics and kinetics at various experimental conditions, such as temperature and metal ion concentration of K(I), Na(I) and Mg(II). Therein, we use optical spectroscopy like UV/VIS spectroscopy and ensemble Förster or Fluorescence Resonance Energy Transfer (FRET) folding studies. Our findings will help to further characterize this newly discovered ribosomal RNA contact and to elucidate its function within the ribosomal maturation process.
The almost complete transcription of the human genome yield in a high number of transcripts, that do not encode proteins. However, the functional elucidation of especially long non cod-ing RNAs is still difficult. Secondary structure analysis is assumed to be a possible method to detect functional relationships of lncRNAs on a large scale, but it is still time consuming and error-prone. GRAPHCLUST, the currently most suitable clustering tool based on RNA secondary structure analysis, lacks mainly in an efficient method for the interpretation of its results. Hence, an independent and interactive RNA clustering interpretation tool was developed to allow visu-alisation and an efficient analysis of RNA clustering results.
The aim of this master thesis is to describe the key factors of successful energy efficiency projects. In particular, local conditions of such projects in Kazakhstan will be emphasized and a country-specific guideline will be provided at the end. The following topics will be covered in this thesis: energy efficiency technologies, financing, and capacities. The first part examines the energy efficiency approaches and their potential in the local industry. The second part deals with available financing methods, their specific characteristics and appropriateness for overcoming investment barriers in Kazakhstan. The third part of the master thesis concerns necessary project capacities. The application of the three elements for successful project implementation is described in the end.
As economies are getting more and more interconnected, the importance of the global logistics sector grew accordingly. However, both structural challenges and current events lead to recent supply chain disruptions, exposing the vulnerabilities of the sector. Simultaneously, blockchain has emerged as a key innovative technology with use cases going far beyond the exchange of virtual currencies. This paper aims to analyze how the technology is transforming global logistics and its challenges. Therefore, six use cases, are presented to give an overview of the technological possibilities of blockchain and smart contracts. The analysis combines theoretical approaches from scientific journals and combines them with findings from real-world implementations. The paper finds that the technology can change supply chain design fundamentally, with processes and decisions being automated and power within supply chain structures changing. However, implementations also face technological, environmental, and organizational challenges that need to be solved for wide-spread adoption.
The Media System of Malawi
(2010)
nicht vorhanden
A relatively new research field of neurosciences, called Connectomics, aims to achieve a full understanding and mapping of neural circuits and fine neuronal structures of the nervous system in a variety of organisms. This detailed information will provide insight in how our brain is influenced by different genetic and psychiatric diseases, how memory traces are stored and ageing influences our brain structure. It is beyond question that new methods for data acquisition will produce large amounts of neuronal image data. This data will exceed the zetabyte range and is impossible to annotate manually for visualization and analysis. Nowadays, machine learning algorithms and specially deep convolutional neuronal networks are heavily used in medical imaging and computer vision, which brings the opportunity of designing fully automated pipelines for image analysis. This work presents a new automated workflow based on three major parts including image processing using consecutive deep convolutional networks, a pixel-grouping step called connected components and 3D visualization via neuroglancer to achieve a dense three dimensional reconstruction of neurons from EM image data.
Die biologische Ammoniumoxidation ist ein zentraler Bestandteil des globalen Stickstoffkreislaufs. Angesichts der extremen Massen Stickstoff anthropogenen Ursprungs in der Umwelt, liegt die Entfernung reaktiven Stickstoffs im Interesse der Umwelt und der öffentlichen Gesundheit. In der folgenden Arbeit werden Bedingungen zur anaeroben Ammoniumoxidation mit Nitrat in einem Anammox-Reaktor untersucht. Dabei wurden 2 Laborreaktoren für eine Zeit von insgesamt 116 Tagen betrieben und beobachtet, die ausschließlich als Elektronendonatoren und Akzeptoren Ammonium und Nitrat enthielten. Zusätzlich wurden Batchkulturen mit Zellen eines Reaktors angezüchtet und auf ihre Gaszusammensetzung abhängig unterschiedlicher Eigenschaften untersucht. Hierbei wurde eine Reihe unterschiedlicher analytischer Quantifizierungsmethoden genutzt und es konnte gezeigt werden, dass ein Abbau unter den Bedingungen stattfindet.
Die aktuelle Forschung zu dieser Reaktion ist spärlich und verleiht der Bachelorarbeit dadurch Relevanz.