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Functions, which can be summarized to the keyword Internet Protocol Television (IPTV) describe the transmission of video services to users via Internet Protocol (IP). Accompanying to this new television transmission path Home Theatre PCs (HTPC) running a so called Media Center platform are more and more entering the living rooms as a companion for the popular LCD and Plasma displays. Perfect ease of use and the visual integration on the screen and also into the living room is raising their acceptance. These HTPCs are a central node for multimedia services such as TV, radio and email within the networked household. Thus, there are good preconditions for the use of a HTPC as end device for Telco operator driven IPTV and telecommunication services. In the context of this diploma thesis possibilities for the provisioning of IPTV and Next Generation Network (NGN) services on a converged multimedia home entertainment platform for the living room will be investigated, especially Vista Media Center platforms. For this reason, standardization activities will be investigated, which deal with the integration of IPTV and telecommunication services into NGN. The validation of the results will be achieved by the design and implementation of a Vista Media Center Add-In, which can be integrated as an IP Multimedia Subsystem (IMS) based User Agent (UA) in ETSI TISPAN Release 2 IPTV infrastructures. Additionally, a Cross Domain messaging service for IMS based UA is created, which enables a cross-network communication between users.
The H.323 umbrella standard describes audiovisual communication over packetswitched networks. This thesis illustrates the standard in detail with regards to architecture and implementation. The second part of this dissertation is dedicated to examining the Gmail Voice and Video plug-in, an Internet-based audiovisual communication platform. In the course of this thesis a secured kiosk environment for the Gmail Voice and Video plug-in is being developed.
When entering waterways that are restricted either in height, width or by another vessel, the behaviour of a ship changes. The most evident effect of navigating in shallow water is the squat which has led to several groundings. Because of pressure differences the vessel is pulled down into the water and the trim is changed. Another shallow water effect is the speed loss due to an increase in resistance which can reduce the maximal speed by upto 50 percent. In general the behaviour of a ship in shallow water is said to be sluggish, meaning that it is more difficult to navigate which affects the radius of the turning circle among others. Sailing parallel to a close-by bank affects the lateral force and the yaw moment. The interaction with other ships has similar effects as bank effects, but is more sophisticated since more parameters play a major role. In this thesis each of these effects is researched by studying several papers by renowned researchers.
Several models are developed which are correspondent with the inherent model of forces and moments of the simulation program. The challenges and obstacles that arised during modelling and implementation are pointed out and solutions or approaches are given.
The Media System of Malawi
(2010)
nicht vorhanden
The aim of this master thesis is to describe the key factors of successful energy efficiency projects. In particular, local conditions of such projects in Kazakhstan will be emphasized and a country-specific guideline will be provided at the end. The following topics will be covered in this thesis: energy efficiency technologies, financing, and capacities. The first part examines the energy efficiency approaches and their potential in the local industry. The second part deals with available financing methods, their specific characteristics and appropriateness for overcoming investment barriers in Kazakhstan. The third part of the master thesis concerns necessary project capacities. The application of the three elements for successful project implementation is described in the end.
The thesis presents an investigation of the question whether it is viable for the English company Essential Care to introduce a direct selling channel in the United Kingdom. The thesis provides an outline of the direct selling and labour market in the United Kingdom, including organisations and legislation for direct selling. A SWOT analysis illustrates the external and internal factors that could have an influence on the feasibility of the project. The main part of the thesis focuses on a market research survey which was conducted in the United Kingdom. Followed by an analysis of the results it provides a detailed outline of the findings. At the end of the thesis the overall findings are summarised and recommendations for Essential Care are presented.
The primary objective of this work and the research at the “Helmholtz-Zentrum für Umweltforschung” was to gain a deeper understanding of the basically transformation processes, especially for nitrogen species, in constructed wetlands. Therefore two different types of laboratory scale model systems, run with two different artificial wastewaters, had been observed for about 4 months. Data about the situation of three nitrogen species (ammonium, nitrate, nitrite), the physical condition of the pore water and the carbon sources contained by the water had been collected and compared. The present work will provide a summary about the actual knowledge of the microbial processes in constructed wetlands and the general character of such constructions. It will explain the different methods used to gain the data which will be later wards discussed with the aid of the created graphs in the final argumentation.
nicht vorhanden
The bachelor thesis is about cis-trans isomerization of Xaa-Pro (Xaa = any amino acid), their quantitative acquisition and the selection of 3D structure information for the prediction with a support vector machine (SVM). The quantitative detection of occurrence of cis-, trans- and cis/trans conformation in membrane proteins will be examined and evaluated. The 3D structure informa-tions include 12 features, the amino acids around proline and are including of proline. These include the inside/outside classification, the real secondary structure, energy consideration, as well as five further amino acid occur properties within a defined radius of the proline. From this information, a data set was created for the SVM. This program is used for the prediction of unknown and known Xaa Pro Isomerisms. The methods for the analysis were implemented with the platform independent programming language Java. Two programs have emerged from the work to a Xaa PIPT for the quantitative detection and extracting structural information and m Xaa-PIPT to the pure prediction of Xaa-Pro isomerism in protein structures. 389 Membrane proteins from the PDB (Protein Data Bank) served as a basis. The data were also statistically analysed and evaluated.
In this work a new method for the prediction of the Xaa-proline (where Xaa is any amino acid) cis/trans isomerization was investigated. By extraction of twelve structural features (real secondary structure, inside/outside classification, properties of the environment around proline and proline itself) a support vector machine (SVM) based prediction approach was evolved. The Java software Xaa-PIPT for structural feature extraction was developed. Based on 4397 (2199 cis and 2198 trans) prolines extracted from non-redundant, globular proteins a classifier was trained using the radial basis function (RBF) kernel. In ten-fold cross-validation it achieved an accuracy of 70.0478 % and a Matthews correlation coefficient (MCC) of 0.4223, a sensitivity of 0.5433 and a specificity of 0.8576. Based on this classifier a lightweight and easy-to-use Java software tool, called m Xaa-PIPT, for the prediction of the Xaa-proline cis/trans isomerization was devel-oped. It was shown that there are correlations between the proline surrounding environment and the isomerization state. m Xaa-PIPT can be used for the evaluation of low-resolution protein structures and theoretical models to improve their quality by the prediction of the Xaa-proline isomerization.
After the expression of the titin-Hsp27-construct with the following purification supplies no satisfied results which makes the realization of the atomic force microscopy not possible. The devel-opment of the structure model by using different bioinformatic methods can establish a model for the protein sequence. As bioinformatic methods the template search by different BLAST runs and free available software like SwissModel, Pcons, ModWeb and other tools are used. Nevertheless, the generated model is not the native conformation and has to be analyzed with other software until a stable conformation of the structure can be predicted. Depending on the time which is provided the generated model is a good approach for the aim this master thesis has.
This thesis looks at Customer Relationship Management in a different way. In order to identify factors that influence the acceptance of one of its components – the analytical CRM – it focuses on theopinion of the company’s employees. The objective of this thesis is to identify factors that positvely influence the acceptance of analytical Customer Relationship Management within organizations.
This paper explores the origins of Maori images in New Zealand film history. Discussing the history of Maori and their society brings us closer to a, once almost extinct, race and its struggle for self-representation and self-governance. By taking an in-depth look at New Zealands film history we get to understand how Maori were the subject of the earliest films and at what time they started making their own films. Combining those elements gives us the opportunity to understand how early images of Maori were created by Pakeha directors. By looking at different films throughout film history shows how Maori images evolved in time, especially when Maori started depicting themselves. This paper not only answers questions about Maori images in film but also tries to make people realise what odds Maori had to overcome in their daily struggle for selfdetermination.
This feasibility study shows possibilities, how logistical concepts can be
improved or reorganized. Therefore, the assambly line for hydraulic blocks at
Bosch Rexroth Changzhou is checked and new ideas are shown. To ensure
comparability, three different cases are considered. Based on this evaluation,
recommendations for further development are displayed.
Die vorliegende Arbeit befasst sich mit der Leistungsmessung während der Strategieentwicklung im Bereich des Einkaufs am Beispiel DANIELI Österreich. Das Hauptziel ist es, dass System von Danieli Österreich darzustellen, um ein Verständnis der Leistungsmessung in der Praxis zu generieren. Die draus erworbenen Kenntnisse sollen weiterführend in einer Analyse dazu dienen, um die tatsächlichen Einsparung in diesen Ländern aufzuzeigen. Aufgrund Vorgaben der Geschäftsführung ist DANIELI Österreich gezwungen 20% seines Einkaufsvolumens im ehemaligen Jugoslawien einzukaufen, weshalb Möglichkeiten sowie Risiken in den Ländern Bosnien und Herzegowina, Serbien und Kroatien dargestellt werden, um die Einkaufsstrategie zu optimieren.
Different small molecule kinase inhibitors, which have an influence on cell growth, proliferation and cell survival were tested alone and in combination with Erlotinib in the Erlotinib-resistant non-small cell lung cancer cell line PC-9ER and Cisplatin in the K-Ras mutant cell line H358. The aim was to find out, which combinations produce the best antiproliferative effects in non-small cell lung cancer cell lines.
The larval zebrafish mutant Knörf has got a not yet identified gen, which is lethal after 14 dpf in a homozygous state. The mutation courses various degenerations and the loss of the regeneration ability. One of these degenerations was first discovered in the retina by a histological section. The mutants retinas show gaps in the IPL at 7 and 8 dpf which number increases during the maturation of the larva. In recent studies a pax 6 staining was performed, which showed that amacrine cells areaffected. Different types of amacrine cells were tested and it was shown that the parvalbuminergic amacrine cells disappear. The staining was performed in a time course. At 5 dpf is no difference between the number of parvalbuminergic amacrine cells in siblings and mutants but then the degeneration starts. At 2 dpa there is thefirst significant difference which increases at later stages and leads nearly to a full disappearance of these cells in the eye. Parvalbumin is not only present in the retina, therefore the brain as another central nervous system structure was examined. In the telencephalon these cells disappear already at 2 dpa. The parvalbuminergic cells are also present in the skeletal muscle of the tail. Here the degeneration starts approximately at the half of the tail and intensifies to distal areas. It was shown, that parvalbuminergic cells in the muscle disappear until 4dpa. The role of parvalbumin is seemed in the binding ofcalcium and therefore it supports the adjustment of the resting potential after an excitation in the central nervous system. In muscles it assists in the slowing of relaxing after a contraction of a muscle.
The main purpose of this thesis is to investigate factors influencing the buying decision of cigarette smokers. To achieve this, different theories concerning consumer buying behavior and factors influencing have been discussed to achieve a deeper understand of consumer behaviour. To enable me comprehend the influence factors that influence the buying decision of a smoker as a consumer, a survey with questionnaires was performed. The results of the survey indicates that brand awareness, quality of the tobacco, price, packaging, advertisement, influence by others and availability are the major factors influencing the buying decision of a smoker, with availability, quality, price and brand awareness having the most effective influence on a smoker.
Proteins are macromolecules that consist of linear-bonded amino acids. They are essential elements in various metabolic processes. The three-dimensional structure of a protein is determined by the order of amino acids, also referred to as the protein sequence. This conformation corresponds to the structural state in which the protein is functionally active. However, relationships between protein sequence, structure and function have not been fully understood yet. Additionally, information about structural properties or even the entire protein structure are crucial for understanding the dynamics that define protein functionality and mechanisms. From this, the role of a protein in its molecular context can be described closely. For instance, interactions can be investigated and comprehended as a biological dynamic network that is sensitive to alternations, i.e. changes which are caused by diseases. Such knowledge can aid in drug design, whereas compounds need to be specifically tailored and adjusted to their molecular targets. Protein energy profile-basedmethods can be applied to investigate protein structures concerning dynamics and alternations. The publications enclosed to this work discuss in general the scientific potentials of energy profilebased techniques and algorithms. On the one hand, changes in stability caused by protein mutations and proteinligand interactions are discussed in the context of energy profiles. On the other hand, energetic relations to protein sequence, structure and function are elucidated in detail. Finally, the presented discussions focus on recent enhancements of the eProS (energy profile suite) database and toolbox. eProS freely provides all elucidated methodologies to the scientific community. Thus, one can address biological questions with the presented methods at hand. Additionally, eProS provides annotations related to foreign databases. This ensures a broad view on biological data and information. In particular, energetic characteristics can be identified which contribute to a protein’s structure and function.
The objective of this diploma thesis is to analyse the results of functional tests carried out on hydraulic valve blocks at Wujin Plant of Bosch Rexroth (Chang-zhou) Co., Ltd., (China). Based on this analysis, tests could be checked for systematic errors and root causes of failures be identified. Finally, this helped i n-crease the first pass yield of testing to release resources so far bound in inefficient testing processes. Furthermore, a tracking mechanism was established to monitor the function of crucial sensors at test benches.
nicht vorhanden
This thesis deals with the possible integration of social media communication in the marketing of the International Rectifier Corporation. The basis for the implementation of the new communication channel is set through a detailed description of basic, theoret ical functions and features of business-to-business communication as well as social media communication. Based on this knowledge the marketing communication of International Rectifier is analyzed and compared to the competitors. The theoretical lessons in combination with the analysis will then be used to develop a competitive and effective social media strategy for International Rectifier.
There are a lot of people taking part in more than one competition. The competitions are also of a different kind. From local events with a small number of participants to international tournaments watched by many viewers. Naturally it becomes necessary a system to assess and compare the success in various competitions.
The existing ranking systems are usually specialized to fit their application area. More general ranking methods also exist. They can be applied to a wide spectrum of competition fields. However these ranking methods are still not universal and don't cover some important features of the competitions.
A totally new ranking system has been developed within the present master thesis. Its primary purpose is to evaluate and measure prestige gained by participants in competitions. The main contribution of the thesis consists of an original mathematical model that makes the ranking system unique.
The developed ranking system claims to be universal and interdisciplinary. It is based on the fundamental element that distinguishes the competition from the non-competition areas, namely standings that rank the participants according to their performance. The universality and the interdisciplinarity of the ranking system make available cross-disciplinary comparisons, which is usually very subjective and difficult for implementation.
The contribution of the master thesis extends beyond the theoretical area. A ranking software that fully implements this novel ranking system has been designed and developed. The software makes the practical benefits of the ranking system immediately available to potential application areas such as sports clubs and universities.
And finally, the developed ranking system offers a new viewpoint to the competitions – as a way of gaining prestige, rather than the traditional viewpoint of demonstrating mastery.
This master thesis investigates a new method for the feature extraction of gray scale images, the so called „Non-Euclidean Principal Component Analysis“ 1. Thereby the standard inner product of the Euclidean space is substituted by a semi inner product in the well known learning rule of Oja and Sanger. The new method is compared with the standard principal component analysis (PCA) by extracting features (feature vectors) of different databases with class labels and judged regarding the accuracies of „Border Sensitive Generalized Learning Vector Quantization“ (BSGLVQ), „Feed Forward Neural Networks“ (FFNN) and the „Support Vector Machines“ (SVM).
This study shows the potential for the make-or-buy theory in several scenarios – production, assembling and development. The evaluation of these possibilities is conducted, based on Bosch’s core competencies. A decision model is developed to support the decision making process. Based on these results, the serial production at RBAC in China is planned and suggestions for setting up the assembly line are given
Target of this Diploma Thesis is the development of a thermal simulation card to analyze the thermal behavior of a LTE PCIe Mini data card for GSM/UMTS based wireless networks in different environments. The power consumption of modern wireless communication systems has increased dramatically during the last years. Especially for the next generation of wireless modem cards the thermal dissipations will be slightly on or even beyond the official guidelines of the components and the whole card. To gain knowledge about the behavior of the data card, it shall be simulated with software as well as real hardware. As the ASIC components are not available yet, a hardware emulation shall be developed. The thesis covers the whole development process from the idea, the conception, the layout to the assembly and the measurements. It starts with finding a way of emulating the mounted components, measuring and powering. Afterwards a card, incorporating the principles found before, will be developed. An additional software simulation gives comparative values against the measurements. After assembling the emulation cards and running reference measurements, trials for temperature improvements will be ran and compared with the simulations.
The main purpose of this Bachelor thesis was to find and to compile comprehensive information on barley genes expressed in the context of pollen embryogen esis. In the present study, this approach was confined to genes that were previously known to be associated with the initiation of embryogenesis in different plant species. First, candidate transcript sequences were identified in barley. Second, transcript and associated genomic sequences were analyzed in silico to provide suitable structural and functional annotations. Finally, the results of one representative example are presented and interpreted in detail. This work aims to contribute to a significantly improved understanding of pollen embryogenesis - a biological phenomenon broadly used for haploid technology in crop improvement.
In this work a novelty detection framework provided by M. Filippone and G. Sanguinetti is considered, which is useful especially when only few training samples are available. It is restricted to Gaussian mixture models and makes use of information theory, applying the Kullback-Leibler divergence. In this work two variations of the framework are presented, applying the symmetric Hellinger divergence and a statistical likelihood approach.
The study “Proteomic and systems biological database analysis of changed proteins from rat brain tissue after diving “ is about system biological testing of proteomic data obtained by rat brain after experimental diving in a pressure chamber. Basically, brain tissue from animal decompression sickness (DCS) was analyzed by mass spectrometry and has given two larger sets of modified proteins. Thereupon, the resulting up- and down-regulated proteins wereidentified and later compared by means of systems of biological databases, in this case GeneGo MetaCoreTM, in order to find similar or various affected cell biological signaling pathways when two different mass-spectrometry methods were compared.
This work concentrates on the frequently used marketing instrument brand personality. Its effect on the consumer and how it drives consumer behaviour through TV advertis-ing are the focus. Scientific material, utilising research results of the last 20 years, has been analysed to investigate this subject. Furthermore, the example of Southern Comfort provides an insight of brand personality being applied to the real world of marketing business.
For the first time it was discovered that ultraviolet radiation with a wavelength of 200 to 400 nm (maximum 365 nm) radiated from a distance of 40 cm (intensity: 3500 mW/cm²) to PMMA altered its surface wettability as well as a roughness at the nanoscale that was observed with an atomic force microscope (AFM). The roughness rises and falls again in a short time ( 1-2days ) after 75 min and 180 min irradiation time. However , during the next 10 days roughness became stabilized and there was no influence of UV if PMMA was stored in air or in a Petri dish out of glass.
nicht vorhanden
This Bachelor thesis provides an experimental validation of the “si-Fi” software, which was designed for RNAi off-target searches and silencing efficiency predictions. The experimental approach is based on using synthetic DNA as RNAi-target as well as RNAi-trigger sequence. The data was generated by two different types of experiments using a transient gene silencing system in bombarded barley epidermal cells. The efficiency of RNAi was estimated by scoring the effect of silencing of the susceptibility-related gene Mlo on resistance of transformed cells to the powdery mildew fungus Blumeria graminis f. sp. hordei by observing reduction of fluorescent signals coming from an RNAi target fused to the green fluorescent protein. The aim of this work was a comparison between in silicio prediction of RNAi efficiency and off-target effects in barley and experimental data.
In recent years the term Cloud has become popular in the world of technology. It is used to describe many different Information Technology offerings, but people are adapting this word without truly understanding it. “Demystifying the Cloud – Drawing the Lines between Technologies and Concepts” by Kevin Arnot takes a look at many levels of the Cloud and gives a comprehensive overview of the technologies and ideas that make it a paradigm shift. The author analyzes the term methodically by leveraging appropriate information from the Internet as well as from experts. An important milestone in understanding the Cloud accurately is differentiating between its components. These include: underlying technologies, the three Cloud Service Models (SaaS, IaaS and PaaS) and how it is deployed, publically or privately. The result is to understand that a Cloud can be composed in different ways and therefore serves exactly the needs of its users. Furthermore, the author describes challenges that individuals and busi-nesses have to deal with equally and reviews possible solutions. Cloud technology will continue to evolve; however, the future business value of the term “Cloud” will depend on how companies continue using or misusing it.
This work examines the impact Web 2.0 has on CRM in journalism. For this purpose the communication strategies of one international, one New Zealand and one exclusively online men’s magazine are compared. Through this comparison changes in the magazines’ approach to CRM are identified and expert interviews with editors give further insight into the dynamic of the evolution CRM and the journalism industry are going through. Finally, the conclusion illuminates the effects this evolution has on CRM in journalism.
PICC Modulation Analysis
(2014)
This diploma thesis discusses interoperability problems between certified RFID readers and transponders based on the ISO/IEC14443 standardand the root cause for them.
The main goal is the definition of new test methodsand parameters that can supplement the existing test regime for such systems and allowthe identification of those problems beforehand.
Purpose: This study addresses issues of occupational mental health among nurses. Factors such as linking role, work and social factors, stress, burnout, depression, absenteeism and the intention of turnover, guides the research. The purpose of this research paper therefore looks forward to answer the question "How to measure the extent at which nurses experience symptoms or risk of depression through various factors such as individual or demographic factors, emotional exhaustion and stressful working situations?"
Design: Data were collected from 9 nurses working for major hospitals located in Germany, Baden-Württemberg (Mannheim and Heidelberg), Bremen, Ukraine and Ghana.
Methods: The design and method utilized in the qualitative and quantitative research methods is a survey, which consists of a questionnaire and biographical Interviews.
Questionnaire was used to collect data, which included demographic and job characte-ristics, job-related stress, emotional labor, and depressive symptoms The PHQ-9, serves to measure the depressive symptoms of the participants and serves as an instrument to back up the Interviews conducted. The questionnaire was evaluated with the SPSS version 21.0. Descriptive statistics, correlations, and frequency were used to analyze and evaluate the data.
Results: The study found out that all the participants who took part in this survey are depressed ranging from minimal to moderate depression. The questionnaire detected approximately 20% of the participants being minimal depressed, 40%, mild depressed and 30% moderate depressed. The composed questions targeted on factors like Occupational Stress and Work strain with factors as well as recognition and appreciation from patients and organization. 77, 80% admitted, they have no recognition and appreciation from colleagues and patients. 44,40% turned out to be very stressed up with
their daily work routine and the other 55,60% finds it only stressful .100% turned out to find Labor disturbances as a stress factor. All the participants are not pleased with their salary which leads to Job dissatisfaction.
Conclusion: The results show that it is necessary to implement programs for nurses to help reduce job-related stress, Preventive and suitable methods should be considered to reduce mental strain before depression manifest itself.
Clinical Relevance: Introducing programs that may help nurses and its organization is the work of Human resource management in nursing organization. Nursing administrators have to understand that, the rate at which nurses have to work and deal with other stressful situations might cause them to suffer depressive symptoms. In other to help this situation, they can aspire to enhance stressful work conditions, develop programs
that subdue job related stress and minimize the expectations of depressive symptoms.
The purpose of this study was to investigate the effects of provocative marketing strategies of different companies in the fashion industry in the first part. The thesis emphasizes on various strategies used by several firms. Furthermore it demonstrates the
different modes of provocation and also the process of a marketing strategy. The second part highlights the opportunities and risks of provocative marketing strategies based on American Apparel.
As widely discussed in literature spatial patterns of amino acids, so-called structural motifs, play an important role in protein function. The functional responsible part of a protein often lies in an evolutionary highly conserved spatial arrangement of only few amino acids, which are held in place tightly by the rest of the structure. In general, these motifs can mediate various functional interactions, such as DNA/RNA targeting and binding, ligand interactions, substrate catalysis, and stabilization of the protein structure.
Hence, characterizing and identifying such conserved structural motifs can contribute to understanding of structurefunction relationships in diverse protein families. Therefore and because of the rapidly increasing number of solved protein structures, it is highly desirable to identify, understand and moreover to search for structural scattered amino acid motifs. The aim of this work was the development and the implementation of a matching algorithm to search for such small structural motifs in large sets of target structures. Furthermore, motif matches were extensively analyzed, statistically assessed and functionally classified. Following a novel approach, hierarchical clustering was combined with functional classification and used to deduce evolutionary structure-function relationships. The proposed methods were combined and implemented to a feature-rich and easy-to-use command line software tool, which is freely available and contributes to the field of structural bioinformatic research.
Protein structures are essential elements in every biological system evolved on earth, where they function as stabilizing elements, signaltransducers or replication machin eries. They are consisting of linear-bonded amino acids, which determine the three-dimensional structure of the protein, whereas the structure in turn determines the function. The native and biological active structure ofa protein can be understood as the folding state of a polypeptide chain at the global minimum of free energy.
By means of protein energy profiling, which is an approach derived from statistical physics it is possible to assign a so called energy profile to a protein structure. Such an energy profile describes the local energetic interaction features of every amino acid within the structure and introduces an energetic point of view, instead of a structural or sequential onto proteins.
This work aims to give a perspective to the question of how we may gain pattern information out of energy profiles. The concrete subjects are energy-mapped Pfam family alignments and investigations on finding motifs or patterns indiscretizised energy profile segments.
Proteins are involved in almost every aspect of life, mediating a wide range of cellular tasks. The protein sequence dictates the spatial arrangement of the residues and thus ultimately the function of a rotein. Huge effort is put into cumbersome structure eludication experiments which obtain models describing the observed spatial conformation of a protein, enabling users to predict their function, to understand their mode of action or to design tailored drugs to cure disease caused by misfolded or misregulated proteins.
However, the result of structure determination experiments are merely models of reality, made under simplifying assumptions - sometimes containing major undetected errors. On the other hand, such experiments are resource demanding and they cannot supply the actual demand.
Thus, scientists are predicting the structure of proteins in silico, resulting in models that are even
more prone to error.
In consequence, the structure biologists search after a practicable definition of structure quality and over the last two decades several model quality assessment programs emerged, measuring the local and global quality of peculiar structures. Seven representatives were studied, regarding the paradigms they follow and the features they use to describe the quality of residues. Their predications were compared, showing that there is almost no common ground among the tools.
Is there a way to combine their statements anyway?
Finally, the accumulated knowledge was used to design a novel evaluation tool, addressing problems previously spotted. Thereby, high quality of its predication as well as superior usability was
key. The strategy was compared to existing approaches and evaluated on suitable datasets.
A number of real time PCR approaches have been published in the literature. In this thesis, the suitability of different real time PCR approaches using hydrolysis probes have been evaluated regarding PCR performance, cost effectiveness as well as handling. The effect of double-quenched probes as well as the impact of the increase of relative Flap endonuclease amount in quantitative real time PCR has been examined. In terms of genotyping a TaqMan™ assay, considered to be the gold-standard in this application, has been tested and compared to phosphorothioate modified probes, allele specific primers, SNAKE primers, an allele specific probe and primer assays as well as an assay using minor groove binder probes. Promising observations have been made in the case of double-quenched probes, phosphorothioate modified probes, SNAKE primers as well as minor groove binder probes.
The following thesis contains a detailed business plan of a formula student combustion racecar. This includes the evaluating of existing knowledge about the car combined with required information about the market and seed capital. Subsequently the already presented plan is described with the interpretation for future business plans. In this connection the acceptance of electro mobility shall be evaluated and first ideas for the presentation of an electric car shall be created.
Die vorliegende Arbeit befasst sich mit der Analyse der kritischen Erfolgsfaktoren für die Zulassung europäischer Industrieprodukte in Indien, anhand eines europäisch entwickelten und produzierten Produktes für die indische Rolling Stock Industrie. Die dabei berücksichtigen Themenschwerpunkte, die im Detail betrachtet sind über: Welche Standards werden derzeit in Indien bzw. in Europa offiziell für den Zulassungsprozess herangezogen? Aktuelle Situation erfassen. Vergleich der technischen Zulassung Standards zwischen IR (Indischen Railway) Standards und
The almost complete transcription of the human genome yield in a high number of transcripts, that do not encode proteins. However, the functional elucidation of especially long non cod-ing RNAs is still difficult. Secondary structure analysis is assumed to be a possible method to detect functional relationships of lncRNAs on a large scale, but it is still time consuming and error-prone. GRAPHCLUST, the currently most suitable clustering tool based on RNA secondary structure analysis, lacks mainly in an efficient method for the interpretation of its results. Hence, an independent and interactive RNA clustering interpretation tool was developed to allow visu-alisation and an efficient analysis of RNA clustering results.
This paper set out to determine what the effect of daily internet usage on a short attention span was and whether this had an effect on academic performance. As described briefly in the introduction this paper consisted of laying the groundwork through defining the relevant terminology, applying the methodology to the Hypotheses and making conclusive statements.
Two Hypotheses were presented to give the paper the aim. While Hypothesis 1 can be proven true through the two-step terminology applied, Hypothesis 2 does not stand up to the scrutiny. For lack of sufficient and specific evidence, the only conclusive statement that can be made regarding it is that it is untrue.
Approx. 80% of the population sample analysed were between the age of 19 – 30 which automatically reduces the analysis, extrapolations and scientific statements to a more specific age group. The other ages represented were almost all above, meaning that the findings could not accurately be applied to older age groups.
Nonetheless, the data collected was accurate and good be applied to prove Hypothesis 1, meaning that daily internet usage breeds and invites a short attention span. For lack of a fitting data collection method, physcial, social, mental factors along with motivation of an individual make up his academic performance. These were factors that could not be taken into consideration.
Conclusively, the author predicts that a present internet connection coupled with the growing popularity of digital technology attention spans will contin ue to stay as short as they are. Individuals will find ways to direct their short attention span where it is needed and apply it as necessary.
Evolution of Game Music : a look at characteristic elements of music in video games across time
(2015)
Music in video games is a subject worth regarding. Nevertheless, it isn't totally explored yet. This thesis shows and explains characteristics every video game music has and explores them regarding the developments in the history of video games. The thesis contains information about video games that inspired the musical evolution of games or that contain music as key part, as well as information about technological advances that influenced the musical evolution.