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The number of Internet of Things (IoT) devices is increasing rapidly. The Trustless Incentivized Remote Node Network, in short IN3 (Incubed), enables trustworthy and fast access to a blockchain for a large number of low-performance IoT devices. Although currently IN3 only supports the verification of Ethereum data, it is not limited to one blockchain due to modularity. This thesis describes the fundamentals, the concept and the implementation of the Bitcoin verification in IN3.
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This study explores the opportunities and risks associated with user-generated content (UGC) in the communication strategies of marketing departments from a business perspective. With the rise of social media and online platforms, UGC has become a powerful tool for brands to engage with their audience, build trust, and enhance brand awareness. However, implementing UGC also comes with inherent risks, including the loss of control over brand messaging, potential negative user-generated content, and legal implications.
To investigate these dynamics, an empirical mixed-methods approach was employed, including expert interviews and a comprehensive literature review. The findings indicate that UGC offers significant opportunities for marketing departments, such as increased customer loyalty, enhanced authenticity, brand awareness, as well as a diverse set of possible content. However, the study also reveals the potential risks associated with UGC, highlighting the importance of managing these risks effectively.
In the following study the properties of the superabsorbent polymer Broadleaf P4 were investigated according to the aim to apply that polymer within constructed wetlands. The application of the polymer in constructed wetlands shall result in an improvement of the removal of pesticides. For that the polymer was given into lab-scale wetlands together with pumice and were compared to a control wetland, which was filled with gravel. The wetlands were running for several weeks in which the nutrient removal was recorded. The polymer was also tested according to its property to adsorb the pesticides before adding the pesticides to the wetland beds.
In this thesis, we implement, correct, and modify the compartmental model described in “Transmission Dynamics of Large Coronavirus Disease Outbreak in Homeless Shelter, Chicago, Illinois, USA, 2020”. Our objective is to engage in reading and understanding scientific literature, reproduce the results, and modify or generalize an existing mathematical model. We provide an overview of epidemiological models, focusing on simple compartmental SEIR models. We correct inaccuracies and misprints in the original implementation and use the limited-memory Broyden–Fletcher–Goldfarb–Shanno algorithm to fit the model’s parameters. Furthermore, we modify the model by introducing an additional compartment. The resulting model has a more intuitive interpretation and relies on fewer assumptions. We also perform the fitting process for this alternative model. Finally, we demonstrate the advantages of our modified implementations and discuss other possible approaches.
In Machine Learning, Learning Vector Quantization(LVQ) is well known as supervised learning method. LVQ has been studied to generate optimal reference vectors because of its simple and fast learning algorithm [12]. In many tasks of classification, different variants of LVQ are considered while training a model. In this thesis, the two variants of LVQ, Generalized Matrix Learning Vector Quantization(GMLVQ) and Generalized Tangent Learning Vector Quantization(GTLVQ) have been discussed. And later, transfer learning technique for different variants of LVQ has been implemented, visualized and we have compared the results using different datasets.
Community acquired pneumonia (CAP) is a very common, yet infectious and sometimes lethal disease. Therefor, this disease is connected to high costs of diagnosis and treatment. To actually reduce the costs for health care in this matter, diagnosis and treatment must get cheaper to conduct with no loss in predictive accuracy. One effective way in doing so would be the identification of easy detectable and highly specific transcriptomic markers, which would reduce the amount of work required for laboratory tests by possibly enhanced diagnosis capability.
Transcriptomic whole blood data, derived from the PROGRESS study was combined with several documented features like age, smoking status or the SOFA score. The analysis pipeline included processing by self organizing maps for dimensionality and noise reduction, as well as diffusion pseudotime (DPT). Pseudotime enabled modelling a disease run of CAP, where each sample represented a state/time in the modelled run. Both methods combined resulted in a proposed disease run of CAP, described by 1476 marker genes. The additional conduction of a geneset analysis also provided information about the immune related functions of these marker genes.
Blockchain and other distributed ledger technologies are evolving into enabling infrastructures for innovative ICT-solutions. Numerous features, such as decentralization, programmability, and immutability of data, have led to a multitude of use cases that range from cryptocurrencies, tracking and tracing to automated business protocols or decentralized autonomous systems. For organizations that seek blockchain adoption, the overwhelming spectrum of potential application areas requires guidance reducing complexity and support the development of blockchain-based concepts. This paper introduces a classification approach to provide design and implementation guidance that goes beyond current textbook classifications. As an outcome, a typology for management and business architects is developed, before the paper concludes with an instantiation of existing use cases and a discussion of their classes.
Influenza A viruses are responsible for the outbreak of epidemics as well as pandemics worldwide. The surface protein neuraminidase of this virus is responsible, among other things, for the release of virions from the cell and is thus of interest in pharmacological research. The aim of this work is to gain knowledge about evolutionary changes in sequences of influenza A neuraminidase through different methods. First, EVcouplings is used with the goal of identifying evolutionary couplings within the protein sequences, but this analysis was unsuccessful. This is probably due to the great sequence length of neuraminidase. Second, the natural vector method will be used for sequence embedding purposes, in hopes to visualize sequential progression of the virus protein over time. Last, interpretable machine learning methods will be applied to examine if the data is classifiable by the different years and to gain information if the extracted information conform to the results from the EVcouplings analysis. Additionally to using the class label year, other labels such as groups or subtypes are used in classification with varying results. For balanced classes the machine learning models performed adequately, but this was not the case for imbalanced data. Groups and subtypes can be classified with a high accuracy, which was not the case for the years, continents or hosts. To identify the minimal number of features necessary for linear separation of neuraminidase group 1 subtypes, a logistic regression was performed at last, resulting in the identification of 15 combinations of nine amino acid frequencies. Since the sequence embedding as well as the machine learning methods did not show neuraminidase evolution over time, further research is necessary, for example with focus on one subtype with balanced data.
Proteins are involved in almost every aspect of life, mediating a wide range of cellular tasks. The protein sequence dictates the spatial arrangement of the residues and thus ultimately the function of a rotein. Huge effort is put into cumbersome structure eludication experiments which obtain models describing the observed spatial conformation of a protein, enabling users to predict their function, to understand their mode of action or to design tailored drugs to cure disease caused by misfolded or misregulated proteins.
However, the result of structure determination experiments are merely models of reality, made under simplifying assumptions - sometimes containing major undetected errors. On the other hand, such experiments are resource demanding and they cannot supply the actual demand.
Thus, scientists are predicting the structure of proteins in silico, resulting in models that are even
more prone to error.
In consequence, the structure biologists search after a practicable definition of structure quality and over the last two decades several model quality assessment programs emerged, measuring the local and global quality of peculiar structures. Seven representatives were studied, regarding the paradigms they follow and the features they use to describe the quality of residues. Their predications were compared, showing that there is almost no common ground among the tools.
Is there a way to combine their statements anyway?
Finally, the accumulated knowledge was used to design a novel evaluation tool, addressing problems previously spotted. Thereby, high quality of its predication as well as superior usability was
key. The strategy was compared to existing approaches and evaluated on suitable datasets.