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RNA tertiary contact interactions between RNA tetraloops and their receptors stabilize the folding of ribosomal RNA and support the maturation of the ribosome. Here we use FRET assisted structure prediction to develop structural models of two ribosomal tertiary contacts, one consisting of a kissing loop and a GAAA tetraloop and one consisting of the tetraloop receptor (TLR) and a GAAA tetraloop. We build bound and unbound states of the ribosomal contacts de novo, label the RNA in silico and compute FRET histograms based on MD simulations and accessible contact volume (ACV) calculations. The predicted mean FRET efficiency from molecular dynamics (MD) simulations and ACV determination show agreement for the KL-TLGAAA construct. The KL construct revealed too high FRET efficiency and artificial dye behavior, which requires further investigation of the model. In the case of the TLR, the importance of the correct dye and construct parameters in the modeling was shown, which also leads to a renewed modeling. This hybrid approach of experiment and simulation will promote the elucidation of dynamic RNA tertiary contacts and accelerate the discovery of novel RNA interactions as potential future drug targets.