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Decentralization is one of the key attributes associated with blockchain technology. Among the different developments in recent years, decentralized autonomous organizations (DAOs) have been of growing interest. DAOs are currently a key part of another emerging use case, namely decentralized science (DeSci). Given the novelty of the field, an integrative definition of DeSci has not been established, but some inherent concepts and ideas can be traced back to the Open Science movement. Although the DeSci movement has the potential to benefit the public, for example through funding underrepresented research areas or more inclusive and transparent research in general, some negative aspects of decentralization should not be neglected. Due to the novelty of blockchain and emerging use cases, research can and should precede mass adoption, to which this paper aims to contribute.